{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:06:58Z","timestamp":1761808018936},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T00:00:00Z","timestamp":1455753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009395","name":"CancerCare Manitoba Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic lymphocytic leukemia and small lymphocytic lymphoma (<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SLL<\/jats:styled-content>) patients in Manitoba are either referred to the <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> Clinic at CancerCare Manitoba (<jats:styled-content style=\"fixed-case\">CCMB<\/jats:styled-content>) or are followed by other hematologists and general practitioners. However, it has been unclear whether referral to the <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> clinic influences patient outcome. Overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) was assessed for all <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SLL<\/jats:styled-content> patients diagnosed in Manitoba between 2007 and 2011. Of 555 patients, 281 (51%) were referred to the <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> clinic. Patients seen in this clinic had a twofold increased <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> compared to patients who were managed by other hematologists and general practitioners (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 2.375, <jats:italic>P<\/jats:italic> 0.0002) when adjusted for age, gender, presence of pre\u2010 or post\u2010<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> cancer, treatment and urban\/rural location. In the nonreferred population there was a striking correlation between advancing age and decreasing <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>. However, this correlation was almost eliminated in the referred population who were more likely to receive chemotherapy. Patients referred and seen in the <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> clinic have an improved <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> compared to nonreferred patients and this appears to be primarily related to improved <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> in the elderly. Possible explanations for this finding are discussed.<\/jats:p>","DOI":"10.1002\/cam4.559","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T16:36:27Z","timestamp":1455813387000},"page":"971-979","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of outcome of patients with CLL who are referred or nonreferred to a specialized <scp>CLL<\/scp> clinic: a Canadian population\u2010based study"],"prefix":"10.1002","volume":"5","author":[{"given":"Sara","family":"Beiggi","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Medical Genetics University of Manitoba 745 Bannatyne Avenue Winnipeg Manitoba R3E 0J9 Canada"},{"name":"Manitoba Institute of Cell Biology Cancer Care Manitoba 675 McDermot Ave Winnipeg Manitoba R3E 0V9 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Versha","family":"Banerji","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Genetics University of Manitoba 745 Bannatyne Avenue Winnipeg Manitoba R3E 0J9 Canada"},{"name":"Manitoba Institute of Cell Biology Cancer Care Manitoba 675 McDermot Ave Winnipeg Manitoba R3E 0V9 Canada"},{"name":"Department of Internal Medicine University of Manitoba 820 Sherbrook Street Winnipeg Manitoba R3E 2N2 Canada"},{"name":"Department of Hematology and Medical Oncology Cancer Care Manitoba 675 McDermot Ave Winnipeg Manitoba R3E 0V9 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Deneka","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Registry Cancer Care Manitoba 675 McDermot Ave Winnipeg Manitoba  R3E 0V9 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Griffith","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Registry Cancer Care Manitoba 675 McDermot Ave Winnipeg Manitoba  R3E 0V9 Canada"},{"name":"Department of Community Health Sciences University of Manitoba 750 Bannatyne Avenue Winnipeg Manitoba  R3E 0W3 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer B.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Genetics University of Manitoba 745 Bannatyne Avenue Winnipeg Manitoba R3E 0J9 Canada"},{"name":"Manitoba Institute of Cell Biology Cancer Care Manitoba 675 McDermot Ave Winnipeg Manitoba R3E 0V9 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James B.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Manitoba Institute of Cell Biology Cancer Care Manitoba 675 McDermot Ave Winnipeg Manitoba R3E 0V9 Canada"},{"name":"Department of Internal Medicine University of Manitoba 820 Sherbrook Street Winnipeg Manitoba R3E 2N2 Canada"},{"name":"Department of Hematology and Medical Oncology Cancer Care Manitoba 675 McDermot Ave Winnipeg Manitoba R3E 0V9 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2009.06.013"},{"key":"e_1_2_6_3_1","first-page":"1888","volume-title":"Wintrobe's Clinical Hematology","author":"Johnston J. 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