{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:22:04Z","timestamp":1792297324260,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["1267"],"award-info":[{"award-number":["1267"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["NET\u20102018\u201012365935"],"award-info":[{"award-number":["NET\u20102018\u201012365935"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Incorporating real\u2010world data in the drug development process allows the improvement of health outcomes by providing better representation of actual patterns of drug safety and efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims and Methods<\/jats:title><jats:p>Here, we present the results of a retroprospective, observational real\u2010life study of 154 patients with myelofibrosis treated with ruxolitinib in a real\u2010life setting in seven Italian centers of the MYNERVA project.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median drug exposure was 29 (range, 3\u201398) months. Discontinuation rate was 27% after a median time of 13 (range, 3\u201361). While hematological toxicities were in line with previous findings, infections occurred frequently, representing a not negligible cause of discontinuation and death. Anemia, symptoms, and spleen responses were obtained at any time in 23%, 91%, and 68% of patients, respectively; most patients achieved their responses by week 24. Larger splenomegaly and delayed treatment initiation correlated with lower spleen response at 24 weeks. Spleen response was associated with a superior overall survival, regardless of DIPSS. Of interest, both achievement and loss of spleen response had prognostic implications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusion<\/jats:title><jats:p>Overall, our findings provide insights on the efficacy and safety of ruxolitinib in a real\u2010world, multicenter cohort of Italian MF patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5618","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T07:35:14Z","timestamp":1674891314000},"page":"8166-8171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Assessment of the efficacy and tolerability of ruxolitinib for the treatment of myelofibrosis patients in a real\u2010life setting: An Italian MYNERVA Project"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0816-5462","authenticated-orcid":false,"given":"Giacomo","family":"Coltro","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence  Florence Italy"},{"name":"CRIMM, Center for Research and Innovation of Myeloproliferative Neoplasms Azienda Ospedaliero\u2010Universitaria Careggi  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Sant'Antonio","sequence":"additional","affiliation":[{"name":"GENOMEC Doctorate School, Medical Genetics, Department of Medical Biotechnologies University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe A.","family":"Palumbo","sequence":"additional","affiliation":[{"name":"Department of Scienze Mediche Chirurgiche e Tecnologie Avanzate \"G.F. Ingrassia\" University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Mannelli","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence  Florence Italy"},{"name":"CRIMM, Center for Research and Innovation of Myeloproliferative Neoplasms Azienda Ospedaliero\u2010Universitaria Careggi  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5178-5827","authenticated-orcid":false,"given":"Valerio","family":"De\u00a0Stefano","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Radiological and Hematological Sciences Catholic University  Rome Italy"},{"name":"Dipartimento DIRE Fondazione Policlinico A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1557-0957","authenticated-orcid":false,"given":"Marco","family":"Ruggeri","sequence":"additional","affiliation":[{"name":"Hematology Department San Bortolo Hospital  Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5576-5412","authenticated-orcid":false,"given":"Elena M.","family":"Elli","sequence":"additional","affiliation":[{"name":"Hematology Division and Bone Marrow Transplantation Unit, San Gerardo Hospital ASST Monza  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Zanotti","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Medicine University Hospital of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Borsani","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine University of Pavia  Pavia Italy"},{"name":"Division of Hematology Fondazione IRCCS Policlinico San Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Bertozzi","sequence":"additional","affiliation":[{"name":"First Medical Clinic, Department of Medicine\u2010DIMED University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Duminuco","sequence":"additional","affiliation":[{"name":"Postgraduate School of Hematology University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Betti","sequence":"additional","affiliation":[{"name":"Dipartimento DIRE Fondazione Policlinico A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Carli","sequence":"additional","affiliation":[{"name":"Hematology Department San Bortolo Hospital  Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Cavalca","sequence":"additional","affiliation":[{"name":"Hematology Division and Bone Marrow Transplantation Unit, San Gerardo Hospital ASST Monza  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Tanasi","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Medicine University Hospital of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7572-9504","authenticated-orcid":false,"given":"Elisa","family":"Rumi","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine University of Pavia  Pavia Italy"},{"name":"Division of Hematology Fondazione IRCCS Policlinico San Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L.","family":"Randi","sequence":"additional","affiliation":[{"name":"First Medical Clinic, Department of Medicine\u2010DIMED University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Garibaldi","sequence":"additional","affiliation":[{"name":"Postgraduate School of Hematology University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6241-1206","authenticated-orcid":false,"given":"Giuseppe G.","family":"Loscocco","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence  Florence Italy"},{"name":"CRIMM, Center for Research and Innovation of Myeloproliferative Neoplasms Azienda Ospedaliero\u2010Universitaria Careggi  Florence 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