{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:39:27Z","timestamp":1747147167862,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Our objective was to correlate cytomorphological features of metastatic non\u2010small cell lung carcinoma (mNSCLC) with maximal standardized uptake value (mSUV) of positron emission tomography (PET) in Lymph nodes (LNs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Positive cytology slides of 114 LNs were reviewed from 100 patients with mNSCLC who had undergone PET study. Student's <jats:italic>t<\/jats:italic>\u2010test was used for statistical comparisons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean patients' age: 68.5, 54% male. LNs locations were: mediastinum: 99, lung hilum: 13, peribronchial: 1, axilla: 1. Final diagnoses were: Adenocarcinoma: 86, squamous cell carcinoma: 28 LNs. Within the adenocarcinoma subgroup, histological patterns correlate with mSUV. Acinar and papillary patterns were associated with significantly lower mSUVs (mean\u00a0\u00b1\u2009standard error (SE): 7.9\u00a0\u00b1\u20090.9 and 9.2\u00a0\u00b1\u20090.8, respectively) than solid pattern (13.0\u00a0\u00b1\u20091.2; <jats:italic>p<\/jats:italic> values: 0.001 and 0.009, respectively). Similar difference exists between patterns associated with low\u2010 and high\u2010grade adenocarcinoma (Mean\u00a0\u00b1\u00a0SE: 9.2\u00a0\u00b1\u20090.8 and 12.0\u00a0\u00b1\u20091.0, respectively. <jats:italic>p<\/jats:italic> value: 0.02). Interestingly, micropapillary pattern was associated with the lowest mSUV amongst all patterns (Mean\u00a0\u00b1\u00a0SE: 5.4\u00a0\u00b1\u20091.1). Other features that correlated with higher mSUV were necrosis, moderate\/severe nuclear atypia, lower lymphoid tissue yield, and contralateral LN involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In LNs with mNSCLC, certain cytomorphological features are associated with higher mSUV. Micropapillary, a pattern considered as high\u2010grade, is associated with lower SUV values; hence, a lower SUV threshold may raise concern for metastasis. Although high SUV is associated with LN metastasis, lower SUV levels in certain adenocarcinomas suggest correlation with clinical and morphological characteristics could be valuable in tailoring therapeutic management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5629","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T06:11:47Z","timestamp":1674540707000},"page":"8218-8227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Do fine needle aspirate cytomorphological features correlate with positron emission tomography findings of metastatic non\u2010small cell lung carcinoma in lymph nodes?"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6430-3607","authenticated-orcid":false,"given":"Kianoosh","family":"Keyhanian","sequence":"first","affiliation":[{"name":"Eastern Ontario Regional Laboratory Association, Department of Pathology and Laboratory Medicine University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harmanjatinder S.","family":"Sekhon","sequence":"additional","affiliation":[{"name":"Eastern Ontario Regional Laboratory Association, Department of Pathology and Laboratory Medicine University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,23]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","first-page":"45","article-title":"Epidemiology of lung cancer","volume":"25","author":"Thandra KC","year":"2021","journal-title":"Contemp Oncol"},{"volume-title":"Canadian Cancer Statistics 2018","year":"2018","author":"Canadian Cancer Statistics Advisory Committee","key":"e_1_2_9_3_1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp132"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-019-0624-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31818307a7"},{"issue":"5","key":"e_1_2_9_7_1","first-page":"918","article-title":"The prognostic significance of fluorodeoxyglucose positron emission tomography imaging for patients with nonsmall cell lung carcinoma. 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