{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:56:05Z","timestamp":1789448165017,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Relapsed or refractory Hodgkin lymphoma (R\/R HL) is a challenging disease with limited treatment options beyond brentuximab vedotin and checkpoint inhibitors. Herein we present the time\u2010trend analysis of R\/R HL patients who received allogeneic hematopoietic cell transplantation (allo\u2010HCT) at our center from 2001\u20132017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The patients were divided into two distinct treatment cohorts: era1 (2001\u20132010), and era2 (2011\u20132017). The primary endpoint was overall survival (OS). Secondary endpoints included progression\u2010free survival (PFS), non\u2010relapse mortality (NRM), and cumulative incidence of acute and chronic graft versus host disease (GVHD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 51 patients included in the study, 29 were in era1, and 22 were in era2. There was decreased use of myeloablative conditioning in era2 (18% vs. 31%) compared to era1 and 95% of patients in era2 previously received brentuximab Vedotin (BV). Haploidentical donors were seen exclusively in era2 (0% vs. 14%) and more patients received alternative donor transplants (7% vs. 32%) in era2. The 4\u2010year OS (34% vs. 83%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001) and 4\u2010year PFS (28% vs. 62%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.001) were significantly inferior in era1 compared to era2. The incidence of 1\u2010year NRM was lower in era2 compared to era1 (5% vs. 34%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.06). The cumulative incidence of acute GVHD at day 100 was similar in both eras (<jats:italic>p<\/jats:italic>\u00a0=\u20090.50), but the incidence of chronic GVHD at 1\u00a0year was higher in era2 compared to era1 (55% vs. 21%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite the advent of novel therapies, allo\u2010HCT remains an important therapeutic option for patients with R\/R HL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5631","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T04:57:56Z","timestamp":1674104276000},"page":"8228-8237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Outcomes associated with allogeneic hematopoietic stem cell transplantation for relapsed and refractory Hodgkin lymphoma in the era of novel agents"],"prefix":"10.1002","volume":"12","author":[{"given":"Muhammad 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