{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:44:26Z","timestamp":1789731866961,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009954","name":"Taiho Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009954","name":"Taiho Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009954","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nab\u2010paclitaxel (nab\u2010PTX) has better transfer to tumor tissue than cremophor\u2010based paclitaxel. It suggests that the optimum dose of nab\u2010PTX might be lower than the dose and schedule that is widely used. We designed a randomized phase II trial to examine the clinical utility and safety of nab\u2010PTX in patients with previously treated advanced non\u2010small cell lung cancer (NSCLC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were randomly allocated (1:1) to receive nab\u2010PTX monotherapy at 100\u2009mg\/m<jats:sup>2<\/jats:sup> (group A) or 70\u2009mg\/m<jats:sup>2<\/jats:sup> (group B). The primary endpoint was progression\u2010free survival (PFS). Secondary endpoints included overall survival (OS), objective response rate (ORR), and adverse events (AEs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Finally, 81 patients were randomized. Similar results were observed in both groups for PFS (3.75 vs. 3.71\u2009months), OS (13.50 vs. 16.13\u2009months), or ORR (20.5% vs. 23.1%). The incidences of grade 3 or worse AEs were 57.5% in group A and 41.5% in group B. The proportion of serious side effects was 10.0% in group A and 4.9% in group B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both standard dose and low dose of nab\u2010PTX monotherapy are active for previously treated NSCLC patients with better safety profile. Therefore, nab\u2010PTX 70\u2009mg\/m<jats:sup>2<\/jats:sup> dose and schedule in the trial would be a reasonable option.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5652","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T17:03:39Z","timestamp":1676999019000},"page":"9133-9143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Standard versus low\u2010dose nab\u2010paclitaxel in previously treated patients with advanced non\u2010small cell lung cancer: A randomized phase <scp>II<\/scp> trial (<scp>JMTO LC14<\/scp>\u201001)"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-0962","authenticated-orcid":false,"given":"Susumu","family":"Takeuchi","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine and Oncology, Graduate School of Medicine Nippon Medical School  Tokyo 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