{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:55:52Z","timestamp":1782489352356,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The role of induction chemotherapy (IC) in oropharyngeal squamous cell carcinoma (OPSCC) remains controversial. Its interpretation can be confounded by heterogeneity in chemosensitivity and human papillomavirus (HPV) status. This study aimed to investigate the prognostic impact of IC response in HPV\u2010positive and \u2010negative OPSCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with OPSCC who underwent IC and concurrent chemoradiotherapy (CCRT) were retrospectively analyzed. Radiologic response to IC by \u226550% was defined as IC\u2010sensitive (IC\u2010s), while lesser response was deemed as IC\u2010resistant (IC\u2010r). Progression\u2010free survival (PFS) and overall survival (OS) were compared between subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 51 HPV\u2010positive and 57 HPV\u2010negative patients were included. IC\u2010s patients accounted for 55.6%, 62.7%, and 49.1% in the entire cohort, HPV\u2010positive, and HPV\u2010negative subgroup, respectively. Compared with IC\u2010r subgroup, IC\u2010s was associated with better clinical outcomes either in the entire cohort (3y\u2010PFS 91.7%vs.43.7%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001; 3y\u2010OS 98.3% vs. 67.4%, <jats:italic>P<\/jats:italic>\u00a0=\u20090.002), the HPV\u2010positive subgroup (3\u2010year PFS 94.7% vs. 47.9%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001; 3\u2010year OS 100% vs. 73.5%, P\u00a0=\u00a00.055) or the HPV\u2010negative subgroup (3\u2010year PFS 88.2% vs. 40.9%, <jats:italic>P<\/jats:italic>\u00a0=\u20090.001; 3\u2010year OS 96.4% vs. 63.1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.026). Multivariate analysis demonstrated that response to IC represents an independent prognosticator for 3\u2010year PFS (HR, 0.088; 95% CI, 0.027\u20130.289; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and 3\u2010year OS (HR, 0.100; 95% CI, 0.021\u20130.477; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Response to IC exerts a critical predictive effect on prognosis of both HPV\u2010positive and \u2010negative OPSCC. Personalized treatment strategy based on IC response is worthy of further exploration in the future.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5656","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T07:59:37Z","timestamp":1674892777000},"page":"9175-9185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Response to induction chemotherapy predicts survival outcomes in oropharyngeal cancer"],"prefix":"10.1002","volume":"12","author":[{"given":"Qixian","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"},{"name":"Shanghai Clinical Research Center for Radiation Oncology  Shanghai China"},{"name":"Shanghai Key Laboratory of Radiation Oncology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5920-808X","authenticated-orcid":false,"given":"Tingting","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"},{"name":"Shanghai Clinical Research Center for Radiation Oncology  Shanghai China"},{"name":"Shanghai Key Laboratory of Radiation Oncology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunying","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"},{"name":"Shanghai Clinical Research Center for Radiation Oncology  Shanghai China"},{"name":"Shanghai Key Laboratory of Radiation Oncology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"},{"name":"Shanghai Clinical Research Center for Radiation Oncology  Shanghai China"},{"name":"Shanghai Key Laboratory of Radiation Oncology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"},{"name":"Shanghai Clinical Research Center for Radiation Oncology  Shanghai China"},{"name":"Shanghai Key Laboratory of Radiation Oncology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-3012","authenticated-orcid":false,"given":"Xiayun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"},{"name":"Shanghai Clinical Research Center for Radiation Oncology  Shanghai China"},{"name":"Shanghai Key Laboratory of Radiation Oncology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"},{"name":"Department of Head and Neck Surgery Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghai","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"},{"name":"Department of Head and Neck Surgery Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6503-0951","authenticated-orcid":false,"given":"Chaosu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"},{"name":"Shanghai Clinical Research Center for Radiation Oncology  Shanghai China"},{"name":"Shanghai Key Laboratory of Radiation Oncology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"},{"name":"Shanghai Clinical Research Center for Radiation Oncology  Shanghai China"},{"name":"Shanghai Key Laboratory of Radiation Oncology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9829-3312","authenticated-orcid":false,"given":"Xueguan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"},{"name":"Shanghai Clinical Research Center for Radiation Oncology  Shanghai China"},{"name":"Shanghai Key Laboratory of Radiation Oncology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.06.015"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.36.4596"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14129"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_10_6_1","unstructured":"Network NCC.(NCCN) clinical practice guidelines in oncology. Head and Neck Cancer Version 1. (2022)"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds065"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2012.43.6097"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(21)00076-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)90011-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.12.008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33491"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2019.06.002"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.68.3300"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-019-01461-6"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2012.43.8820"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt555"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33452"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.26.4819"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn011"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12136"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.01.031"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2013.53.5633"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.11276"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071028"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070956"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.08.007"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0208"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509x.175601"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30516"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.42"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.5656","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.5656","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.5656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T01:49:24Z","timestamp":1692582564000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.5656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,27]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/cam4.5656"],"URL":"https:\/\/doi.org\/10.1002\/cam4.5656","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,27]]},"assertion":[{"value":"2022-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}