{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:39:32Z","timestamp":1747147172088,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Current guidelines recommend using filgrastim or tbo\u2010filgrastim to mobilize hematopoietic progenitor cells in an autologous setting. However, previous studies have suggested other forms of granulocyte colony\u2010stimulating factor (G\u2010CSF) are equally efficacious, possibly with fewer leukaphereses required. Thus, we prospectively studied the efficacy of lenograstim, a glycosylated recombinant form of G\u2010CSF, in multiple myeloma (MM) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From November 2011 to January 2020, 98\u2009MM patients undergoing autologous stem cell transplant (ASCT) from five academic centers in Korea were enrolled. Patients were mobilized with subcutaneous lenograstim (Neutrogin\u00ae) with fixed doses of 10\u00a0\u03bcg\/kg for 4\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most of the patients ( <jats:italic>N<\/jats:italic> \u00a0=\u00a090, 91.8%) achieved at least the targets of 2\u2009\u00d7\u200910<jats:sup>6<\/jats:sup> CD34+ cells\/kg body weight, and more than half of MM patients ( <jats:italic>N<\/jats:italic> \u00a0=\u00a057, 58.2%) reached a target of 5\u2009\u00d7\u200910<jats:sup>6<\/jats:sup> CD34+ cells\/kg body weight. The mobilization failure rate was 8.2% ( <jats:italic>N<\/jats:italic> \u00a0=\u00a08). The median number of CD34\u2009+\u2009cell\/kg using G\u2010CSF only was 5.25\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\/kg (range 0.49\u201313.47). Adverse events included transfusion (TF, <jats:italic>N<\/jats:italic> \u00a0=\u00a053, 54.1%), bone pain ( <jats:italic>N<\/jats:italic> \u00a0=\u00a06, 6.1%), fever ( <jats:italic>N<\/jats:italic> \u00a0=\u00a02, 2.0%), and gastrointestinal troubles ( <jats:italic>N<\/jats:italic> \u00a0=\u00a02, 2.0%). There were no grade 3 or 4 adverse events during mobilization. Body surface area (BSA) at mobilization and platelet TF were factors associated with CD34+ collection. Most patients achieved neutrophil ( <jats:italic>N<\/jats:italic> \u00a0=\u00a093, 98.9%) and platelet ( <jats:italic>N<\/jats:italic> \u00a0=\u00a089, 95.7%) engraftment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lenograstim can safely and effectively mobilize stem cells in MM autologous settings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5657","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T14:24:02Z","timestamp":1679581442000},"page":"9186-9193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mobilization of hematopoietic stem cells with lenograstim in multiple myeloma patients: Prospective multicenter observational study (<scp>KMM122<\/scp>)"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3057-4502","authenticated-orcid":false,"given":"Eun Hee","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1780-5553","authenticated-orcid":false,"given":"Ja Min","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"},{"name":"Cancer Research Institute Seoul National University College of Medicine  Seoul South Korea"},{"name":"Center for Medical Innovation, Biomedical Research Institute Seoul National University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1753-8846","authenticated-orcid":false,"given":"Dong\u2010Yeop","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul South 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