{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:07:01Z","timestamp":1779232021356,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001707","name":"Union for International Cancer Control","doi-asserted-by":"publisher","award":["TF\/18\/620110"],"award-info":[{"award-number":["TF\/18\/620110"]}],"id":[{"id":"10.13039\/501100001707","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The north and north\u2010eastern regions of India have among the highest incidence of gallbladder cancer (GBC) in the world. We\u00a0report\u00a0the\u00a0clinicopathological\u00a0charateristics\u00a0and\u00a0outcome\u00a0of\u00a0GBC\u00a0patients\u00a0in\u00a0India.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electronic medical records of patients diagnosed with GBC at\u00a0Tata\u00a0Medical\u00a0Center,\u00a0Kolkata\u00a0between 2017 and 2019 were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 698 cases of confirmed GBC with a median age of 58 (IQR: 50\u201365) years and female:male ratio of 1.96. At presentation, 91% (496\/544) had stage III\/IV disease and 30% (189\/640) had incidental GBC. The 2\u2010year overall survival (OS) was 100% (95% CI: 100\u2013100); 61% (95% CI: 45\u201383); 30% (95% CI: 21\u201343); and 9% (95% CI: 6\u201313) for stages I\u2013IV, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u2009&lt;0.0001). \u00a0\u00a0For all patients, the 2\u2010year OS in patients who had a radical cholecystectomy followed by adjuvant therapy (<jats:italic>N<\/jats:italic>\u00a0=\u200936) was 50% (95% CI: 39\u201364), compared to 29% (95% CI: 22\u201338) for those who had a simple cholecystectomy and\/or chemotherapy (<jats:italic>N<\/jats:italic>\u00a0=\u2009265) and 9% (95% CI: 6\u201314) in patients who were palliated (<jats:italic>N<\/jats:italic>\u00a0=\u2009107) (<jats:italic>p<\/jats:italic>\u00a0=\u2009&lt;0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combined surgical\/chemotherapy approach for patients with stage II GBC showed the best outcomes. Early detection of GBC remains problematic with the majority of patients presenting with stage III\u2013IV and who have a median survival of 9.1\u00a0months. Our data suggests that the tumor is chemoresponsive and multi\u2010center collaborative clinical trials to identify alternative therapies are urgently required.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5677","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T12:59:07Z","timestamp":1676293147000},"page":"9293-9302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Characteristics and outcomes of gallbladder cancer patients at the Tata Medical Center, Kolkata 2017\u20132019"],"prefix":"10.1002","volume":"12","author":[{"given":"Anindita","family":"Dutta","sequence":"first","affiliation":[{"name":"Cell Biology Tata Translational Cancer Research Centre  Kolkata India"},{"name":"Division of Cancer Sciences University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2109-3248","authenticated-orcid":false,"given":"Tushar","family":"Mungle","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Tata Translational Cancer Research Centre  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandita","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Cell Biology Tata Translational Cancer Research Centre  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pritha","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Tata Translational Cancer Research Centre  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anisha","family":"Gehani","sequence":"additional","affiliation":[{"name":"Department of Radiology Tata Medical Center  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saugata","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Radiology Tata Medical Center  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohandas","family":"Mallath","sequence":"additional","affiliation":[{"name":"Department of Digestive Diseases Tata Medical Center  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paromita","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Histopathology Tata Medical Center  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6769-3847","authenticated-orcid":false,"given":"Shekhar","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Division of Cancer Sciences University of Manchester  Manchester UK"},{"name":"Clinical Research Unit Tata Translational Cancer Research Centre  Kolkata India"},{"name":"Department of Paediatric Haematology and Oncology Tata Medical Center  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandip","family":"Ganguly","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Tata Medical Center  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudeep","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Hepatobiliary Surgery Tata Medical Center  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manas","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Hepatobiliary Surgery Tata Medical Center  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2916-9649","authenticated-orcid":false,"given":"Vaskar","family":"Saha","sequence":"additional","affiliation":[{"name":"Cell Biology Tata Translational Cancer Research Centre  Kolkata India"},{"name":"Division of Cancer Sciences University of Manchester  Manchester UK"},{"name":"Department of Paediatric Haematology and Oncology Tata Medical Center  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"issue":"6","key":"e_1_2_9_2_1","first-page":"99","article-title":"Gallbladder cancer: epidemiology and outcome","volume":"2014","author":"Hundal R","year":"2014","journal-title":"Clin Epidemiol"},{"issue":"1","key":"e_1_2_9_3_1","first-page":"24","article-title":"Epidemiology of digestive tract cancers in India IV. 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