{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:52:19Z","timestamp":1761630739472},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The frequency of malignancy is increasing in kidney transplant recipients. Posttransplant malignancy (<jats:styled-content style=\"fixed-case\">PTM<\/jats:styled-content>) is a major cause of long\u2010term graft survival inhibition. In this study, we evaluated the frequency and prognosis of <jats:styled-content style=\"fixed-case\">PTM<\/jats:styled-content> at our center and examined the efficacy of cancer screening. Between 1972 and 2013, 750 patients were followed\u2010up at our center. Annual physical examinations and screenings were performed to detect <jats:styled-content style=\"fixed-case\">PTM<\/jats:styled-content>. We investigated the detail of two distinctive cancer groups: screening\u2010detected cancers and symptom\u2010detected cancers. Seventy\u2010seven <jats:styled-content style=\"fixed-case\">PTM<\/jats:styled-content> were identified during the follow\u2010up period. The mean age at the initial <jats:styled-content style=\"fixed-case\">PTM<\/jats:styled-content> detection was 43.6\u00a0\u00b1\u00a012.8\u00a0years. The mean interval from transplantation to cancer diagnosis was 134.5\u00a0\u00b1\u00a011.3\u00a0months. Among the 77 patients, posttransplant lymphoproliferative disease (<jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>) was the most common cancer (19.5%, 15\/77), followed by renal cell carcinoma (15.6%, 12\/77). Of the cancer cases, 46.8% (36\/77) were detected via screening. The most frequently screening\u2010detected cancer was renal cell carcinoma of the native kidney and breast cancer (22.2%, 8\/36). However, it was difficult to detect <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>, urothelial carcinoma, and colorectal cancer via screening. Interestingly, Cox proportional regression analyses revealed nonscreened recipients to be a significant prognostic factor for <jats:styled-content style=\"fixed-case\">PTM<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). This study is the first to report that appropriate screening tests play a key role in early <jats:styled-content style=\"fixed-case\">PTM<\/jats:styled-content> diagnosis and lead to reduce the mortality rate in kidney transplant recipients. These findings support the provision of long\u2010term appropriate screening for kidney transplant recipients.<\/jats:p>","DOI":"10.1002\/cam4.568","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T06:56:42Z","timestamp":1450681002000},"page":"153-158","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The benefits of cancer screening in kidney transplant recipients: a single\u2010center experience"],"prefix":"10.1002","volume":"5","author":[{"given":"Taigo","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Kakuta","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyofumi","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Okumi","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Graduate School of Medicine  Shinjyuku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotsugu","family":"Ichimaru","sequence":"additional","affiliation":[{"name":"Advanced Technology for Transplantation Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Takahara","sequence":"additional","affiliation":[{"name":"Advanced Technology for Transplantation Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Nonomura","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00332.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02385.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181a07a57"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61050-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1592"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c570"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.09.013"},{"issue":"3","key":"e_1_2_7_9_1","first-page":"S1","article-title":"KDIGO clinical practice guideline for the care of kidney transplant recipients","volume":"9","author":"Kidney Disease: Improving Global Outcomes Transplant Work Group","year":"2009","journal-title":"Am. 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