{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T16:14:53Z","timestamp":1776442493784,"version":"3.51.2"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["22987"],"award-info":[{"award-number":["22987"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastric cancer (GC) incidence is declining heterogeneously worldwide. We aimed to calculate updated mortality trends for GC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated time trends for selected countries using the World Health Organization database. We computed age\u2010standardized mortality rates (ASMR) per 100,000 persons over the 1990\u20132019 period. We reported rates for the 2010\u20132014 and 2015\u201319 calendar periods, and the corresponding percent changes. We used joinpoint regression analysis to identify changes in the slope of mortality trends, and predict the number of deaths and rates for 2025. We also reported 2008\u20132012 incidence rates of cardia and noncardia GC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mortality trends from GC have been favorable since 1990 for all countries analyzed and the European Union (EU 27), in both sexes and all ages. GC mortality is predicted to decline in all countries for both sexes, except for French and US women aged 35\u201364\u2009years, and Canadian men aged 35\u201364. The highest proportions of cardia GC were observed in Northern and Central Europe while the lowest ones in Southern and Eastern Europe. Elsewhere, the highest proportions were registered in countries with low incidence and mortality rates, whereas high\u2010mortality countries showed lower proportions of cardia GC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Observed and predicted GC mortality trends declined in most countries in both sexes, with few exceptions, likely due to the control of GC risk factors, in particular <jats:italic>Hp<\/jats:italic> infection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5685","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T11:42:13Z","timestamp":1677152533000},"page":"9912-9925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Trends in gastric cancer mortality 1990\u20132019 in 36 countries worldwide, with predictions to 2025, and incidence, overall and by subtype"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2309-7365","authenticated-orcid":false,"given":"Giulia","family":"Collatuzzo","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Santucci","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Malvezzi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"La\u00a0Vecchia","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Boffetta","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"},{"name":"Stony Brook Cancer Center Stony Brook University  Stony Brook New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Negri","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-017-0575-8"},{"key":"e_1_2_10_3_1","volume-title":"Global cancer observatory: cancer today"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31288-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28999"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12514"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000480"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.54.2.78"},{"key":"e_1_2_10_9_1","unstructured":"https:\/\/www.wcrf.org\/cancer\u2010trends\/stomach\u2010cancer\u2010statistics\/"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.15403\/jgld-3795"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1291446"},{"key":"e_1_2_10_12_1","volume-title":"WHO mortality database","author":"World Health Organization Statistical Information System","year":"2020"},{"key":"e_1_2_10_13_1","volume-title":"International Statistical Classification of Disease and Related Health Problems: 10th Revision","author":"World Health Organization","year":"1992"},{"key":"e_1_2_10_14_1","first-page":"7","volume-title":"Global Health Estimates Technical Paper WHO\/DDI\/DNA\/GHE\/2020.2","author":"World Health Organization","year":"2020"},{"key":"e_1_2_10_15_1","unstructured":"Pan American Health Organization (PAHO).Health Information Platform for the Americas. Available at:https:\/\/www.paho.org\/data\/index.php\/en\/106\u2010cat\u2010data\u2010en\/308\u2010poblacion\u2010nac\u2010en.html?showall=101."},{"key":"e_1_2_10_16_1","unstructured":"European Commission. EUROSTAT population database. Available at:https:\/\/ec.europa.eu\/eurostat\/web\/main\/data\/database(Last accessed January 2022)."},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.18356\/b19523c6-en"},{"key":"e_1_2_10_18_1","first-page":"671","volume-title":"Cancer Incidence in Five Continents","author":"Doll R","year":"1982"},{"key":"e_1_2_10_19_1","unstructured":"National Cancer Institute.Joinpoint Regression Program version 4.9.1. 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