{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:13:11Z","timestamp":1789578791910,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,2,12]],"date-time":"2023-02-12T00:00:00Z","timestamp":1676160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>SARS\u2010CoV\u20102 vaccines cause acute ipsilateral lymph node swelling in an important proportion of vaccines. Thus far, no malignant lymphadenopathies have been reported in temporal context to vaccination in the ipsilateral draining lymph node areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental design<\/jats:title><jats:p>Prompted by two cases with unilateral axillary lymphomas that occurred ipsilaterally to prior SARS\u2010CoV\u20102 vaccination, we systematically retrieved all B\u2010cell non\u2010Hodgkin lymphomas at two German University Medical Centers diagnosed before and after introduction of SARS\u2010CoV\u20102 vaccines in Germany. Available lymphoma tissue (n=19) was subjected to next\u2010generation immunosequencing of the IGH locus. Malignant clonotypes were mined in the CoVabDab database and published data sets from 342 uninfected individuals, 55 individuals 28 days after anti\u2010SARS\u2010CoV\u20102 vaccination and 139 individuals with acute COVID\u201019 together encompassing over 1 million CDR3 sequences in total.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 313 newly diagnosed cases in the two centers and observation periods, 27 unilateral manifestations in the defined deltoid draining regions were identified. The majority thereof were diffuse large B\u2010cell lymphomas (18 of 27 cases). Eleven unilateral cases were diagnosed in the era of SARS\u2010CoV\u20102 vaccination and 16 in the control period before introduction of such vaccines. Of the 11 unilateral lymphomas that occurred during the vaccination period, ten had received a SARS\u2010CoV\u20102 vaccine prior to lymphoma diagnosis. These cases were further evaluated. While left\u2010sided were more frequent than right\u2010sided lymphomas (19 vs 8 cases), no statistically significant association of vaccination site and laterality of the lymphoma manifestation was found. The unilateral lymphomas showed a normal range of B\u2010cell receptors typically found in these lymphoma subtypes with no evidence for anti\u2010SARS\u2010CoV\u20102 sequences in the malignant clonotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Together, we found no evidence that the current SARS\u2010CoV\u20102 vaccines could serve as a trigger for lymphomagenesis in the draining lymph node areas of the deltoid region used for vaccination.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5687","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T06:14:50Z","timestamp":1676268890000},"page":"9313-9321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["No association of malignant B\u2010cell <scp>non\u2010Hodgkin<\/scp> lymphomas with ipsilateral <scp>SARS\u2010CoV<\/scp>\u20102 vaccination"],"prefix":"10.1002","volume":"12","author":[{"given":"Luise 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