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However, no study has systematically analyzed the clinicopathological features,\n STAT<\/jats:styled-content>\n 6 immunoexpression status, or the fusion variants of\n \n NAB<\/jats:styled-content>\n 2\u2010\n STAT<\/jats:styled-content>\n 6\n <\/jats:italic>\n in intrathoracic\n SFT<\/jats:styled-content>\n s. Fifty\u2010two intrathoracic\n SFT<\/jats:styled-content>\n s were retrieved to appraise histopathology, assess\n STAT<\/jats:styled-content>\n 6 immunoexpression, and determine\n \n NAB<\/jats:styled-content>\n 2\u2010\n STAT<\/jats:styled-content>\n 6\n <\/jats:italic>\n fusion variants by\n RT<\/jats:styled-content>\n \u2010\n PCR<\/jats:styled-content>\n . Location\u2010relevant histologic mimics served as controls. Thirty\u2010one pleura\u2010based, 12 mediastinal\/pericardial, and nine intrapulmonary lesions were histologically categorized into eight malignant, eight atypical, and 36 conventional or cellular\n SFT<\/jats:styled-content>\n s, including two fat\u2010forming and two giant cell angiofibroma\u2010like\n SFT<\/jats:styled-content>\n s.\n STAT<\/jats:styled-content>\n 6 distinctively decorated the tumoral nuclei in 51 (98%)\n SFT<\/jats:styled-content>\n s. However, no nuclear staining was observed in the histological mimics.\n \n NAB<\/jats:styled-content>\n 2\u2010\n STAT<\/jats:styled-content>\n 6\n <\/jats:italic>\n fusion was detected in 34\n SFT<\/jats:styled-content>\n s. Twenty\u2010nine (85.3%) exhibited the major\n \n NAB<\/jats:styled-content>\n 2ex4\u2010\n STAT<\/jats:styled-content>\n 6ex2\/3\n <\/jats:italic>\n variant and 5 (14.7%) the minor\n \n NAB<\/jats:styled-content>\n 2ex6\u2010\n STAT<\/jats:styled-content>\n 6ex16\/17\n <\/jats:italic>\n .\n \n NAB<\/jats:styled-content>\n 2ex4\u2010\n STAT<\/jats:styled-content>\n 6ex2\n <\/jats:italic>\n was significantly associated with older age (\n P<\/jats:italic>\n \u00a0=\u00a00.01) and pleuropulmonary tumors (\n P<\/jats:italic>\n \u00a0=\u00a00.025). After a median follow\u2010up of 33.9 (range, 0.3\u2013174.6) months, adverse outcomes occurred in one atypical and five malignant\n SFT<\/jats:styled-content>\n s, including two local relapses, one intrapulmonary metastasis, and three extrathoracic metastases. Inferior disease\u2010free survival was univariately associated with atypical\/malignant histology (\n P<\/jats:italic>\n \u00a0=\u00a00.001) and a mitosis >4\/10\n HPF<\/jats:styled-content>\n s (\n P<\/jats:italic>\n \u00a0=\u00a00.0012) but was unrelated to fusion variants. In conclusion, the majority of intrathoracic\n SFT<\/jats:styled-content>\n s exhibited\n STAT<\/jats:styled-content>\n 6 nuclear staining, and\n \n NAB<\/jats:styled-content>\n 2ex4\u2010\n STAT<\/jats:styled-content>\n 6ex2\/3\n <\/jats:italic>\n was the predominant fusion type. However, clinical aggressiveness is associated with atypical\/malignant histology primarily contributed by increased mitosis but was unrelated to the\n \n NAB<\/jats:styled-content>\n 2\u2010\n STAT<\/jats:styled-content>\n 6\n <\/jats:italic>\n fusion variants.\n <\/jats:p>","DOI":"10.1002\/cam4.572","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T02:00:47Z","timestamp":1450663247000},"page":"159-168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["The clinicopathological significance of\n \n NAB<\/scp>\n 2\u2010\n STAT<\/scp>\n 6\n <\/i>\n gene fusions in 52 cases of intrathoracic solitary fibrous tumors"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-4434","authenticated-orcid":false,"given":"Shih\u2010Chiang","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pathology Chang Gung Memorial Hospital Chang Gung University College of Medicine Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Chi\u2010Mei Medical Center Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chien","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Pathology Shuang Ho Hospital Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u2010Chieh","family":"Chuang","sequence":"additional","affiliation":[{"name":"Departments of Pathology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Chun","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Pathology Changhua Christian Hospital Changhua Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen\u2010Wei","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology E\u2010Da Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Chen","family":"Yu","sequence":"additional","affiliation":[{"name":"Departments of Pathology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuan\u2010Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Departments of Pathology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jui","family":"Lan","sequence":"additional","affiliation":[{"name":"Departments of Pathology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao\u2010Lun","family":"Yen","sequence":"additional","affiliation":[{"name":"Departments of Pathology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Chun","family":"Lin","sequence":"additional","affiliation":[{"name":"Departments of Orthopedics Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tse\u2010Ching","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Chang Gung Memorial Hospital Chang Gung University College of Medicine Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.8430"},{"key":"e_1_2_7_3_1","first-page":"80","volume-title":"WHO classification of tumours of soft tissue and bone","author":"Fletcher C. 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