{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:34:18Z","timestamp":1757705658721,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Certain angiotensin receptor blockers (ARBs) have peroxisome proliferator\u2010activated receptor\u2010\u03b3 (PPAR\u2010\u03b3) activation property, which has been associated with improved programmed cell death ligand 1 blockade and cytotoxic T lymphocyte\u2010mediated antitumor activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study to investigate the impact of PPAR\u2010\u03b3\u2010activating ARBs on patient survival in patients treated with immune checkpoint inhibitors (ICIs) across all types of cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 167 patients receiving both angiotensin receptor blockers (ARBs) and immune checkpoint inhibitors (ICIs) were included. Compared with non\u2010PPAR\u2010\u03b3\u2010ARB users (<jats:italic>n<\/jats:italic>\u00a0=\u2009102), PPAR\u2010\u03b3\u2010ARB users (<jats:italic>n<\/jats:italic>\u00a0=\u200965) had a longer median overall survival (not reached [IQR, 16.0\u2014not reached] vs. 18.6 [IQR, 6.1\u201338.6] months) and progression\u2010free survival (17.3 [IQR, 5.1\u2014not reached] vs. 8.2 [IQR, 2.4\u201318.6] months). In Cox regression analysis, the use of PPAR\u2010\u03b3\u2010activating ARBs had an approximately 50% reduction in all\u2010cause mortality and disease progression. Patients who received PPAR\u2010\u03b3\u2010activating ARBs also had higher clinical benefit rates than non\u2010PPAR\u2010\u03b3\u2010ARB users (82% vs. 61%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of ARBs with PPAR\u2010\u03b3\u2010activating property is linked with better survival among patients receiving ICIs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5734","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T10:29:10Z","timestamp":1677234550000},"page":"9583-9588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The impact of peroxisome proliferator\u2010activated receptor\u2010\u03b3 activating angiotensin receptor blocker on outcomes of patients receiving immunotherapy"],"prefix":"10.1002","volume":"12","author":[{"given":"Cho\u2010Han","family":"Chiang","sequence":"first","affiliation":[{"name":"Department of Medicine Mount Auburn Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Cheng","family":"Chang","sequence":"additional","affiliation":[{"name":"Da Vinci Minimally Invasive Surgery Center Chung Shan Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih\u2010Syuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Da Vinci Minimally Invasive Surgery Center Chung Shan Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan\u2010Jen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine Taipei Veterans General Hospital  Taipei 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