{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:13:39Z","timestamp":1788351219940,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2023YFS0187"],"award-info":[{"award-number":["2023YFS0187"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2023NSFSC1484"],"award-info":[{"award-number":["2023NSFSC1484"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902129"],"award-info":[{"award-number":["81902129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,4]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Cross\u2010lineage expression of the myeloid\u2010associated antigens CD13\/CD33 is common in adult B\u2010lymphoblastic leukemia (B\u2010ALL) patients, yet its prognostic value is still controversial.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a retrospective study of 1005 de novo adult B\u2010ALL patients from January 2009 to December 2019 in our hospital. Logistic and Cox regression were used to analyze the prognostic value of CD13\/CD33 expression in B\u2010ALL. A Cox regression model was established to predict overall survival (OS) for B\u2010ALL patients.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 1005 B\u2010ALL patients, 53.7% (\n n<\/jats:italic>\n \u00a0=\u00a0540) aberrantly expressed CD13\/CD33 (CD13\/CD33\n +<\/jats:sup>\n ). Patients in the CD13\/CD33\n +<\/jats:sup>\n group showed a higher incidence of BCR::ABL1 rearrangement and minimal\/measurable residual disease (MRD) positivity but similar complete remission rate, relapse\u2010free survival, mortality, and OS with CD13\/CD33\n \u2010<\/jats:sup>\n . CD13\/CD33\n +<\/jats:sup>\n patients had a higher risk of MRD positivity than CD13\/CD33\n \u2010<\/jats:sup>\n patients. Notably, CD13\/CD33\n +<\/jats:sup>\n patients who underwent tyrosine kinase inhibitor (TKI) therapy had a better long\u2010term prognosis than those without TKI experience. Sex, group based on CD13\/CD33 expression and TKI experience and white blood cell count were variables independently associated with OS. The Cox regression model integrating these three variables showed a moderate performance for OS prediction (C\u2010index: 0.724).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In real\u2010world practice, CD13\/CD33 expression can predict the risk of MRD in patients without TKI experience, but has no adverse effect on the prognosis of adult B\u2010ALL patients. Incorporating CD13\/CD33 into the standard antibody panels of B\u2010ALL diagnosis and MRD measurements can help predict relapse risk and decisions on therapy options.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cam4.5739","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T10:10:12Z","timestamp":1679566212000},"page":"9615-9626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic value of cross\u2010lineage expression of the myeloid\u2010associated antigens\n CD13<\/scp>\n and\n CD33<\/scp>\n in adult B\u2010lymphoblastic leukemia: A large real\u2010world study of 1005 patients"],"prefix":"10.1002","volume":"12","author":[{"given":"Hongyan","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine West China Hospital of Sichuan University Chengdu 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