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We aimed to address this gap through a Bayesian network meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed network analysis from randomized controlled trials comparing these treatments: PD\u2010(L)1 inhibitor, CTLA\u20104 inhibitor, CXCR inhibitor, PARP inhibitor, CDK inhibitor, chemotherapy, and their combinations. Pooled estimations of progression\u2010free survival, overall survival, objective response rate, and toxicity (systematic and specific) were conducted within the Bayesian framework.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five trials involving 9 strategies were included. In terms of progression\u2010free survival and overall survival, PD\u2010(L)1 inhibitor combined with cisplatin\/carboplatin (P) and etoposide (E) shown the acknowledged superiority than other treatments. The addition of CTLA\u20104 inhibitor (ipilimumab) to EP had the highest response rate among these regimens, and the combination of chemotherapy (irinotecan) and cisplatin\/carboplatin had the greatest probability of performing considerable systematic security. The secondary endpoint was specific adverse events, including vomiting, fatigue, thrombocytopenia, constipation, and decreased appetite; hence we depicted the specific toxicity profile of each regimen. In addition, we identified the differences between PD\u20101 inhibitors and PD\u2010L1 inhibitors in prolonging overall survival time for the central nervous system (CNS)\/liver metastases patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EP combined with PD\u2010(L)1 inhibitor followed by CTLA\u20104 inhibitors or anti\u2010angiogenesis was the considerable treatment with considerable efficacy and safety for ES\u2010SCLC. Each treatment has a unique specific toxicity profile, which needs more attention.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5750","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T14:21:29Z","timestamp":1679581289000},"page":"10230-10242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and toxicity profile of <scp>first\u2010line<\/scp> treatment for extensive\u2010stage small cell lung cancer: A Bayesian network <scp>meta\u2010analysis<\/scp>"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8254-7530","authenticated-orcid":false,"given":"Guo","family":"Lin","sequence":"first","affiliation":[{"name":"Thoracic Oncology Ward, Cancer Center, West China Hospital Sichuan University  Chengdu, Sichuan China"},{"name":"Laboratory of Clinical Cell Therapy, West China Hospital Sichuan University  Chengdu, Sichuan 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