{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:25:57Z","timestamp":1781796357559,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["5U54CA118948"],"award-info":[{"award-number":["5U54CA118948"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prognostic value of mucinous adenocarcinomas (MCAs, exhibiting &gt;50% extracellular mucin) of the colorectum, in relation to their anatomic location is not well studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We compared MCAs (<jats:italic>n<\/jats:italic>\u00a0=\u2009175) with non\u2010MCAs (NMCAs, <jats:italic>n<\/jats:italic>\u00a0=\u20091015) and the cancer\u2010specific survival rates were evaluated, based on their anatomic site, by univariate Kaplan\u2013Meier and multivariate Cox methods. Subsets of these tumors were immunostained for MUC1, MUC2, Bcl\u20102, and p53.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MCAs were more commonly found in the right colon, were of high\u2010grade, and were more prevalent in younger patients (&lt;40\u2009years). They exhibited strong expression of MUC2 and Bcl\u20102 and showed less p53 nuclear staining. In contrast, most NMCAs were low\u2010grade with high expression of MUC1. MCAs of the rectum were associated with poorer outcomes relative to NMCAs (HR 1.85, CI 95% 1.15\u20132.97), even though the distributions of advanced\u2010stage tumors were similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Late\u2010stage disease and age were poor independent prognostic indicators of cancer\u2010specific deaths across all tumor locations. In summary, rectal MCAs have a poor prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5803","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T12:15:02Z","timestamp":1678796102000},"page":"9637-9643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Immunophenotypic profiles and prognosis for colorectal mucinous adenocarcinomas are dependent on anatomic location"],"prefix":"10.1002","volume":"12","author":[{"given":"Chirag","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Pathology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5162-322X","authenticated-orcid":false,"given":"Michael","family":"Behring","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Al\u00a0Diffalha","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"O'Neal Comprehensive Cancer Center University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepti","family":"Dhall","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"O'Neal Comprehensive Cancer Center University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrakumar","family":"Shanmugam","sequence":"additional","affiliation":[{"name":"Department of Pathology RVM Institute of Medical Sciences &amp; Research Center, KNR University of Health Sciences  Siddipet India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Grizzle","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"O'Neal Comprehensive Cancer Center University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1545-3032","authenticated-orcid":false,"given":"Upender","family":"Manne","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"O'Neal Comprehensive Cancer Center University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101174"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.140"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000487710"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr062"},{"issue":"5","key":"e_1_2_12_6_1","first-page":"5791","article-title":"Trends of incidence and survival in patients with gastrointestinal mucinous adenocarcinoma","volume":"16","author":"Zong Z","year":"2018","journal-title":"Oncol Lett"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970620)74:3<346::AID-IJC19>3.0.CO;2-9"},{"issue":"10","key":"e_1_2_12_8_1","first-page":"4017","article-title":"Racial differences in the prognostic usefulness of MUC1 and MUC2 in colorectal adenocarcinomas","volume":"6","author":"Manne U","year":"2000","journal-title":"Clin Cancer Res"},{"key":"e_1_2_12_9_1","first-page":"135","volume-title":"Molecular Pathology of Early Cancer","author":"Grizzle WE","year":"1999"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-11-0315"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113193"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000635"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000658"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.57"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-019-0361-0"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6986870"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.5803","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.5803","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.5803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T01:46:25Z","timestamp":1692582385000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.5803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,14]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/cam4.5803"],"URL":"https:\/\/doi.org\/10.1002\/cam4.5803","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,14]]},"assertion":[{"value":"2022-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}