{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:01:40Z","timestamp":1792292500306,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009812","name":"Chinese Society of Clinical Oncology","doi-asserted-by":"publisher","award":["Y\u2010XD202001\u20100152"],"award-info":[{"award-number":["Y\u2010XD202001\u20100152"]}],"id":[{"id":"10.13039\/501100009812","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22YF1408200"],"award-info":[{"award-number":["22YF1408200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Large B\u2010cell lymphoma with <jats:italic>IRF4<\/jats:italic> rearrangement (LBCL, <jats:italic>IRF4<\/jats:italic>+) has been recently recognized as a specific entity that is frequently associated with young age and favorable prognosis. However, whether the good outcome of the disease is due to <jats:italic>IRF4<\/jats:italic>+ or other factors remains obscure. We thus analyzed 100 young patients with primary head and neck LBCL to see the clinicopathologic correlates of <jats:italic>IRF4<\/jats:italic>+.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The histopathology, immunophenotype, <jats:italic>IRF4<\/jats:italic> status of the tumors, and clinical data were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one tumors were diagnosed as LBCL, <jats:italic>IRF4<\/jats:italic>+, which were more frequently associated with a follicular growth pattern, medium\u2010sized blastoid cytology, germinal center B\u2010cell\u2010like, and CD5+ phenotype, compared with IRF4\u2212 ones. While most of the patients received chemotherapy with or without radiation, eight <jats:italic>IRF4<\/jats:italic>+ patients received mere surgical resection of the tumor and exhibited excellent outcome. <jats:italic>IRF4<\/jats:italic>+ cases featured a significantly higher complete remission rate, and better survivals compared with <jats:italic>IRF4<\/jats:italic>\u2212 ones. Multivariate analysis confirmed <jats:italic>IRF4<\/jats:italic>+ correlates with a better survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our work confirmed the unique clinicopathologic features of LBCL, <jats:italic>IRF4<\/jats:italic>+, and disclosed for the first time the independent favorable prognostic impact of <jats:italic>IRF4<\/jats:italic>+. These findings may further unravel the heterogeneity of LBCL occurring in youth, and aid in risk stratification and tailoring the therapeutic strategy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5828","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T05:30:04Z","timestamp":1682055004000},"page":"10684-10693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["<scp><i>IRF4<\/i><\/scp> rearrangement may predict favorable prognosis in children and young adults with primary head and neck large B\u2010cell lymphoma"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5079-4783","authenticated-orcid":false,"given":"Xiang\u2010Nan","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Pathology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College, Fudan University  Shanghai 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