{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:48:04Z","timestamp":1756385284231,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T00:00:00Z","timestamp":1679702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies had explored the diagnostic or prognostic value of NRP\u20101\/CD304 in blastic plasmacytoid dendritic cell neoplasm (BPDCN), acute myeloid leukemia (AML), and B\u2010cell acute lymphoblastic leukemia (B\u2010ALL), whereas the expression and application value of NRP\u20101\/CD304 in other common hematological diseases have not been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Bone marrow samples from 297 newly diagnosed patients with various hematological diseases were collected to detect the expression of NRP\u20101\/CD304 by flow cytometry (FCM). The diagnostic efficacy of NRP\u20101\/ CD304\u2010positive diseases was analyzed by receiver operating characteristic (ROC) curve, and the area under the ROC curve (AUC) was compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the research cohort, the total positive rate of NRP\u20101\/CD304 was 14.81% (44\/297), mainly distributed in BPDCN (100%, 6\/6), B\u2010ALL (48.61%, 35\/72), and AML (4.48%, 3\/67), with statistically significant differences (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.01). Other diseases, such as T\u2010cell acute lymphoblastic leukemia (T\u2010ALL), B\u2010cell non\u2010Hodgkin lymphoma (B\u2010NHL), T\/NK\u2010cell lymphoma and plasma cell neoplasms, did not express NRP\u20101\/CD304. The AUC of NRP\u20101\/CD304 was 0.936 (95% CI 0.898\u20130.973), 0.723 (95% CI 0.646\u20130.801), and 0.435 (95% CI 0.435) in BPDCN, B\u2010ALL and AML, respectively. Besides, CD304 was commonly expressed in B\u2010ALL with BCR\u2010ABL1 gene rearrangement (<jats:italic>p<\/jats:italic>\u00a0=\u20090.000), and CD304 expression was positively correlated with CD34 co\u2010expression (<jats:italic>p<\/jats:italic>\u00a0=\u20090.009) and CD10 co\u2010expression (<jats:italic>p<\/jats:italic>\u00a0=\u20090.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NRP\u20101\/CD304 is only expressed in BPDCN, B\u2010ALL and AML, but not in other common hematological diseases. This indicates that NRP\u20101\/CD304 has no obvious diagnostic and follow\u2010up study value in hematological diseases other than BPDCN, B\u2010ALL, and AML.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5838","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T19:49:03Z","timestamp":1679773743000},"page":"11284-11292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of diagnostic efficacy of <scp>NRP<\/scp>\u20101\/<scp>CD304<\/scp> in hematological diseases"],"prefix":"10.1002","volume":"12","author":[{"given":"Yi\u2010jun","family":"Liu","sequence":"first","affiliation":[{"name":"Sun Yat\u2010sen University Cancer Center  Guangzhou Guangzhou 510060 People's Republic of China"},{"name":"State Key Laboratory of Oncology in South China  Guangzhou Guangzhou 510060 People's Republic of China"},{"name":"Collaborative Innovation Center for Cancer Medicine  Guangzhou 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