{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:19:27Z","timestamp":1786965567592,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T00:00:00Z","timestamp":1679702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The first HPV\u2010vaccine eligible cohorts in the Netherlands will enter the cervical screening program in 2023. However, a substantial number of young women already have had a cervical sample taken before entry into the regular screening program. This study was initiated to explore early effects of HPV vaccination on detection of cytological abnormalities in cervical samples of women younger than the screening age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Results of cervical samples were obtained from the Dutch National Pathology Databank (PALGA) and were linked to the women's HPV vaccination status from the national vaccination registry (Praeventis) (<jats:italic>N<\/jats:italic>\u00a0=\u200942,171). Occurrence of low\u2010grade and high\u2010grade squamous intraepithelial lesions or worse (LSIL and HSIL+) and high\u2010risk HPV positive tests (hrHPV) in the first cervical sample were compared between vaccinated and unvaccinated women by multivariable logistic regression analysis, corrected for age at cervical sampling and age of vaccination (12\/13\u2009years, \u2265\u00a0=\u00a014\u2009years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For fully vaccinated women (three\u2010 or two\u2010dose schedule), statistically significant reductions were seen for all outcomes compared to unvaccinated women (hrHPV: adjusted OR, 0.70, 95% CI, 0.63\u20130.79; LSIL: 0.70, 0.61\u20130.80; HSIL+: 0.39, 0.30\u20130.51).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>By linking nation\u2010wide registries on pathology and vaccination, we show significant beneficial early effects of HPV\u2010vaccination on LSIL, HSIL+, CIN3\/AIS\/carcinoma and hrHPV detection in young women upto 24\u2009years of age who have a cervical sample taken before entry into the cervical cancer screening program.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5842","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T19:50:05Z","timestamp":1679773805000},"page":"11786-11794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Early effect of bivalent human papillomavirus vaccination on cytology outcomes in cervical samples among young women in the Netherlands"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7702-9288","authenticated-orcid":false,"given":"Tessa M.","family":"Schurink\u2010van\u00a0\u2019t\u00a0Klooster","sequence":"first","affiliation":[{"name":"Department National Immunisation Programme, Centre for Infectious Disease Control National Institute for Public Health and the Environment  Bilthoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert G.","family":"Siebers","sequence":"additional","affiliation":[{"name":"PALGA  Houten The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joske","family":"Hoes","sequence":"additional","affiliation":[{"name":"Department National Immunisation Programme, Centre for Infectious Disease Control National Institute for Public Health and the Environment  Bilthoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folkert J.","family":"van Kemenade","sequence":"additional","affiliation":[{"name":"Department of Pathology Erasmus Medical Centre  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Berkhof","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Data Science Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes A.","family":"Bogaards","sequence":"additional","affiliation":[{"name":"Department National Immunisation Programme, Centre for Infectious Disease Control National Institute for Public Health and the Environment  Bilthoven The Netherlands"},{"name":"Department of Epidemiology and Data Science Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hester E.","family":"de Melker","sequence":"additional","affiliation":[{"name":"Department National Immunisation Programme, Centre for Infectious Disease Control National Institute for Public Health and the Environment  Bilthoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,25]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"WHO.Fact sheet: Human papillomavirus (HPV) and cervical cancer.2020Updated 11 November 2020. Available from:https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/human\u2010papillomavirus\u2010(hpv)\u2010and\u2010cervical\u2010cancer"},{"key":"e_1_2_11_3_1","volume-title":"The National Immunisation Programme in the Netherlands: surveillance and developments in 2019\u20132020","author":"Schurink\u2010van 't Klooster TM","year":"2020"},{"key":"e_1_2_11_4_1","unstructured":"European Medicines Agency (EMA). Available from:https:\/\/www.ema.europa.eu\/en."},{"key":"e_1_2_11_5_1","unstructured":"RIVM.HPV vaccination. Accessed 3 December 2020.Available from:https:\/\/www.rivm.nl\/en\/hpv\u2010vaccination."},{"key":"e_1_2_11_6_1","volume-title":"Immunization Coverage National Immunization Programme in the Netherlands: Year of Report 2011","author":"Lier E","year":"2011"},{"key":"e_1_2_11_7_1","volume-title":"Immunisation Coverage and Annual Report National Immunisation Programme in the Netherlands 2020","author":"Lier EA","year":"2021"},{"key":"e_1_2_11_8_1","unstructured":"RIVM.Cervical cancer screening programme. Accessed 3 December 2020.Available from:https:\/\/www.rivm.nl\/en\/cervical\u2010cancer\u2010screening\u2010programme"},{"issue":"1","key":"e_1_2_11_9_1","first-page":"19","article-title":"Pathology databanking and biobanking in the Netherlands, a central role for PALGA, the nationwide histopathology and cytopathology data network and archive","volume":"29","author":"Casparie M","year":"2007","journal-title":"Cell Oncol"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.011841"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2018.0298"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.08.061"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy067"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix582"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31568"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30035"},{"issue":"5","key":"e_1_2_11_17_1","article-title":"Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors","volume":"5","author":"Arbyn M","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw354"},{"key":"e_1_2_11_19_1","unstructured":"World Health Organization (WHO).Global Vaccine Action Plan 2011\u20132020.2013Available from:http:\/\/www.who.int\/immunization\/global_vaccine_action_plan\/GVAP_doc_2011_2020\/en\/"},{"key":"e_1_2_11_20_1","unstructured":"RIVM. RIVM expands HPV vaccination programme: girls and boys protected from six types of cancer with one vaccine. Available from:https:\/\/www.rivm.nl\/en\/news\/rivm\u2010expands\u2010hpv\u2010vaccination\u2010programme\u2010girls\u2010and\u2010boys\u2010protected\u2010from\u2010six\u2010types\u2010of\u2010cancer\u2010with"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.5842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T12:44:47Z","timestamp":1695905087000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.5842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,25]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/cam4.5842"],"URL":"https:\/\/doi.org\/10.1002\/cam4.5842","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,25]]},"assertion":[{"value":"2022-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}