{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:23:40Z","timestamp":1784633020221,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["cstc2021ycjh\u2010bgzxm0022"],"award-info":[{"award-number":["cstc2021ycjh\u2010bgzxm0022"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072723"],"award-info":[{"award-number":["82072723"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Growing evidences suggest that circular RNAs (circRNAs) are important factors in cancer progression. Nevertheless, the role of circRNAs in the progression of pancreatic ductal adenocarcinoma (PDAC) remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CircPTPRA was identified based on our previous circRNA array data analysis. Wound healing, transwell, and EdU assays were performed to investigate the effect of circPTPRA on the migration, invasion, and proliferation of PDAC cells in vitro. RNA pull\u2010down, fluorescence in situ hybridization (FISH), RNA immunoprecipitation (RIP), and dual\u2010luciferase reporter assays were conducted to verify the binding of circPTPRA with miR\u2010140\u20105p. Subcutaneous xenograft model was constructed for in vivo experiment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CircPTPRA was significantly upregulated in PDAC tissues and cells compared to normal controls. Moreover, circPTPRA overexpression was positively correlated with lymph node invasion and worse prognosis in PDAC patients. In addition, overexpression of circPTPRA promoted PDAC migration, invasion, proliferation, and epithelial\u2010mesenchymal transition (EMT) in vitro and in vivo. Mechanistically, circPTPRA upregulates LaminB1 (LMNB1) expression by sponging miR\u2010140\u20105p and ultimately promotes the progression of PDAC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study revealed that circPTPRA plays an important role in the progression of PDAC by sponging miR\u2010140\u20105p. It can be explored as a potential prognostic marker and therapeutic target for PDAC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5869","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T05:06:03Z","timestamp":1681275963000},"page":"11651-11671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>CircPTPRA<\/scp> promotes the progression of pancreatic ductal adenocarcinoma via the <scp>miR<\/scp>\u2010140\u20105p\/<scp>LMNB1<\/scp> axis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-2756","authenticated-orcid":false,"given":"Wen","family":"Fu","sequence":"first","affiliation":[{"name":"Chongqing Medical University  Chongqing 400016 China"},{"name":"Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences  Chongqing 400174 China"},{"name":"Chongqing School University of Chinese Academy of Sciences  Chongqing 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