{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:27:00Z","timestamp":1761895620989},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T00:00:00Z","timestamp":1361404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated responses to the treatment and long\u2010term outcomes of chronic myeloid leukemia patients treated with imatinib as first\u2010line treatment in routine clinical setting from two countries with centralized tyrosine kinase inhibitors (<jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content>s) treatment. We assessed prognostic significance of European LeukemiaNet (<jats:styled-content style=\"fixed-case\">ELN<\/jats:styled-content>) 2006\u2010 and 2009\u2010defined responses and the prognostic value of molecular responses at defined time points on 5\u2010year survivals. Among the cumulative rates of incidence of hematologic, cytogenetic, and molecular responses and all important survival parameters, we evaluated the prognostic significance of different <jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content> transcript\u2010level ratios (\u22641%; &gt;1%\u2013\u226410%; &gt;10%) at 3, 6, 12, and 18\u00a0months (<jats:italic>n<\/jats:italic>\u00a0=\u00a0199). The <jats:styled-content style=\"fixed-case\">ELN<\/jats:styled-content> optimal response criteria and their predictive role were significantly beneficial for event\u2010free survival at all given time points. We found significant improvement in survivals of patients with <jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content> lower than 10% in the 6th and 12th months. Significantly better outcome was found in patients who achieved major molecular response (<jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content>) in the 12th month. The cumulative incidences of complete cytogenetic response (<jats:styled-content style=\"fixed-case\">CCyR<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content> were significantly associated with the molecular response in the 3rd month. The <jats:styled-content style=\"fixed-case\">ELN<\/jats:styled-content> response criteria and their predictive role were helpful at given time points; however, the 2009 definition did not significantly alter the prognostic accuracy compared with that of the 2006 definition. The significant value was observed for cytogenetic responses at the 6th and 12th month. Moreover, progression\u2010free and event\u2010free survivals were improved with <jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content> at the 12th month.<\/jats:p>","DOI":"10.1002\/cam4.59","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T04:30:56Z","timestamp":1361507456000},"page":"216-225","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of 5\u2010year imatinib treatment of 458 patients with <scp>CP<\/scp>\u2010<scp>CML<\/scp> in routine clinical practice and prognostic impact of different <scp>BCR<\/scp>\u2010<scp>ABL<\/scp> cutoff levels"],"prefix":"10.1002","volume":"2","author":[{"given":"Hana","family":"Klamov\u00e1","sequence":"first","affiliation":[{"name":"Institute of Hematology and Blood Transfusion Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate\u0159ina Machov\u00e1","family":"Pol\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Transfusion Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Mu\u017e\u00edk","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Analyses Masaryk University Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zden\u011bk","family":"R\u00e1\u010dil","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hematology and Oncology University Hospital and Masaryk University Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"\u017d\u00e1\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hematology and Oncology University Hospital and Masaryk University Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate\u0159ina","family":"Steinerov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Haematooncology University Hospital Plze\u0148 Plze\u0148 Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Karas","sequence":"additional","affiliation":[{"name":"Department of Haematooncology University Hospital Plze\u0148 Plze\u0148 Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Haematooncology University Hospital Olomouc Olomouc Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Deme\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Haematology and Blood Transfusion University Hospital Bratislava Bratislava Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzana","family":"Michalovi\u010dov\u00e1\u2010Sninsk\u00e1","sequence":"additional","affiliation":[{"name":"Department of Haematology and Blood Transfusion University Hospital Bratislava Bratislava Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslava","family":"Voglov\u00e1","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine Division of Hematology University Hospital Hradec Kr\u00e1lov\u00e9 Hradec Kr\u00e1lov\u00e9 Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u013dudmila","family":"Demitrovi\u010dov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Haematology and Blood Transfusion National Cancer Institute Bratislava Bratislava Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Miku\u0161kov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Haematology and Blood Transfusion National Cancer Institute Bratislava Bratislava Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"T\u00f3thov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncohematology L. Pasteur University and UPJS\u0160 Ko\u0160ice Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juraj","family":"Chudej","sequence":"additional","affiliation":[{"name":"Department of Haematology and Blood Transfusion University Hospital Martin Martin Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imrich","family":"Markuljak","sequence":"additional","affiliation":[{"name":"Department of Haematology FD Roosevelt University Hospital and Health Care Centre Bansk\u00e1 Bystrica Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Cmunt","sequence":"additional","affiliation":[{"name":"1st Department of Internal Medicine General University Hospital Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Moravcov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Transfusion Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Dvo\u0159\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Haematooncology University Hospital Plze\u0148 Plze\u0148 Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyra","family":"Michalov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Transfusion Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Jaro\u0161ov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Haematooncology University Hospital Olomouc Olomouc Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark\u00e9ta Markov\u00e1","family":"\u0160\u0165astn\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Transfusion Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Cetkovsk\u00fd","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Transfusion Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ladislav","family":"Du\u0160ek","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Analyses Masaryk University Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladim\u00edr","family":"Koza","sequence":"additional","affiliation":[{"name":"Department of Haematooncology University Hospital Plze\u0148 Plze\u0148 Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Trn\u011bn\u00fd","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Transfusion Prague Czech Republic"},{"name":"1st Department of Internal Medicine General University Hospital Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel","family":"Indr\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Haematooncology University Hospital Olomouc Olomouc Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61165-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-038943"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062867"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V114.22.1126.1126","article-title":"MD11 International Randomized Study of Interferon and STI571 (IRIS) 8\u2010year follow\u2010up: sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase treated with imatinib","volume":"114","author":"Deininger M.","year":"2009","journal-title":"Blood"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-005686"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.0779"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2005.01.008"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdj106"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403033"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.85"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.6565"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404983"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.168"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V116.21.893.893","article-title":"Stability of conversion factors for BCR\u2010ABL monitoring \u2013 implications for the frequency of validation rounds","volume":"116","author":"M\u00fcller M. 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