{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:45:07Z","timestamp":1783529107529,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T00:00:00Z","timestamp":1683331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2021\u2010I2M\u20101\u2010053"],"award-info":[{"award-number":["2021\u2010I2M\u20101\u2010053"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Metabolites of tryptophan (Trp) metabolism in the tumor microenvironment play crucial immunosuppressive roles in various cancers. However, the role of Trp metabolism in diffuse large B\u2010cell lymphoma (DLBCL) or natural killer\/T\u2010cell lymphoma (NK\/TCL) remains unelucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated the potential role of Trp metabolism in a cohort of 43 patients with DLBCL and 23 with NK\/TCL. We constructed tissue microarrays and performed in situ staining of Trp\u2010catabolizing enzymes and PD\u2010L1 using immunohistochemistry (IHC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed 14.0% positive staining of IDO1 in DCBCL and 60.9% in NK\/TCL; 55.8% of IDO2 in DCBCL and 95.7% in NK\/TCL; 79.1% of TDO2 in DCBCL and 43.5% in NK\/TCL; 29.7% of IL4I1 in DCBCL and 39.1% in NK\/TCL. However, IDO1, IDO2, TDO2, and IL4I1 positivity did not significantly differ between PD\u2010L1+ and PD\u2010L1\u2212 biopsy tissue samples of NK\/TCL; nonetheless, a positive correlation of IDO1 (<jats:italic>r<\/jats:italic>\u2009=\u20090.87, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), IDO2 (<jats:italic>r<\/jats:italic>\u2009=\u20090.70, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), TDO2 (<jats:italic>r<\/jats:italic>\u2009=\u20090.63, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and IL4I1 (<jats:italic>r<\/jats:italic>\u2009=\u20090.53, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) with PD\u2010L1 expression was observed in the TCGA\u2010DLBCL dataset. Finally, immunohistochemical (IHC) analysis revealed the lack of superior prognostic effect with higher expression of Trp enzymes in DLBCL and NK\/TCL. Furthermore, IDO1, IDO2, TDO2, and IL4I1 expression, as well as survival rates, did not significantly differ across all groups in the TCGA\u2010DLBCL cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Collectively, our findings provide novel insights into the enzymes involved in Trp metabolism in DLBCL and NK\/TCL and their association with PD\u2010L1 expression, which offers potential strategies to combine Trp\u2010metabolism enzyme inhibitors with anti\u2010PD\u2010L1 or other immunotherapeutic strategies in clinical DLBCL or NK\/TCL treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5903","type":"journal-article","created":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T19:10:00Z","timestamp":1683400200000},"page":"12139-12148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Expression of Tryptophan Metabolism Enzymes in Patients with Diffuse Large B\u2010cell Lymphoma and <scp>NK<\/scp>\/T\u2010cell Lymphoma"],"prefix":"10.1002","volume":"12","author":[{"given":"Dan","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Medical Research Center, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"Clinical Biobank, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3096-5092","authenticated-orcid":false,"given":"Yuming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunyao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Research 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