{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:35:58Z","timestamp":1777646158336,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The development of immune\u2010related adverse events (irAEs) may be associated with clinical efficacy of checkpoint inhibitors (CPIs) in patients with cancer. We therefore investigated the effect of irAEs and pre\u2010treatment parameters on outcome in a large, real\u2010life patient cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single\u2010centre, retrospective, observational study including patients who received CPIs from 2011 to 2018 and followed until 2021. The primary outcome was overall survival, and the secondary outcome was the development of irAEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 229 patients with different tumour entities (41% non\u2010small cell lung cancer [NSCLC], 29% melanoma) received a total of 282 CPI treatment courses (ipilimumab, nivolumab, pembrolizumab or atezolizumab). Thirty\u2010four percent of patients developed irAEs (of these 17% had CTCAE Grade\u2009\u22653). Factors independently associated with mortality were pre\u2010treatment CRP \u226510\u2009mg\/L (hazard ratio [HR] 2.064, <jats:italic>p<\/jats:italic>\u2009=\u20090.0003), comorbidity measured by Charlson comorbidity index (HR 1.149, <jats:italic>p<\/jats:italic>\u2009=\u20090.014) and irAEs (HR 0.644, <jats:italic>p<\/jats:italic>\u2009=\u20090.036) (age\u2010adjusted, <jats:italic>n<\/jats:italic>\u2009=\u2009216). Baseline eosinophil count \u22640.2\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L was a further independent predictor of mortality (age\u2010, CRP\u2010, CCI\u2010 and irAE\u2010adjusted HR\u2009=\u20092.252, <jats:italic>p<\/jats:italic>\u2009=\u20090.002, <jats:italic>n<\/jats:italic>\u2009=\u2009166). Anti\u2010CTLA\u20104 use (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and pre\u2010treatment CRP &lt;10\u2009mg\/L were independently associated with irAE occurrence (<jats:italic>p<\/jats:italic>\u2009=\u20090.037).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found an independent association between irAE occurrence and improved overall survival in a real\u2010life cohort spanning multiple tumour entities and treatment regimens. Pre\u2010treatment comorbidities, CRP and eosinophil count represent potential markers for predicting treatment response.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5919","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T13:14:07Z","timestamp":1682082847000},"page":"12253-12262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Pre\u2010treatment comorbidities, C\u2010reactive protein and eosinophil count, and immune\u2010related adverse events as predictors of survival with checkpoint inhibition for multiple tumour entities"],"prefix":"10.1002","volume":"12","author":[{"given":"Tarun","family":"Mehra","sequence":"first","affiliation":[{"name":"Department of Oncology Medical University Clinic  Kantonsspital Baselland Liestal Switzerland"},{"name":"Department of Oncology &amp; Hematology University Hospital Z\u00fcrich, University of Zurich  Z\u00fcrich 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