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The primary end point of overall response rate in the intent\u2010to\u2010treat analysis was 41.5% and 38.1% in the standard and extended dosing arms, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.660). Complete remission and marrow complete remission also did not differ between the two arms. Cytopenia was the most frequent adverse event (76.4%). The median duration of neutropenia per cycle did not differ between the two arms during the first two cycles, but significantly shorter in the extended dosing arm in the third cycle (8.5 vs. 15.5\u2009days, <jats:italic>p<\/jats:italic>\u2009=\u20090.049) and in the fourth cycle (8 vs. 14\u2009days, <jats:italic>p<\/jats:italic>\u2009=\u20090.294).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The 5\u2010day 20\u2010mg\/m<jats:sup>2<\/jats:sup>\/day and 8\u2010day 12\u2010mg\/m<jats:sup>2<\/jats:sup>\/day decitabine regimens have similar efficacy and safety in patients with intermediate or high risk MDS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5922","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T00:37:43Z","timestamp":1687653463000},"page":"13885-13893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Decitabine in patients with myelodysplastic syndromes: A multi\u2010center, open\u2010label, dose comparison trial"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1969-6015","authenticated-orcid":false,"given":"Hui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hematology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute of Hematology Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruixiang","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated 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