{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:53:55Z","timestamp":1789754035328,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T00:00:00Z","timestamp":1683331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cancer is currently the second leading cause of death globally. There is much uncertainty regarding the comparative risks of new\u2010onset overall cancer and pre\u2010specified cancer for Type 2 diabetes mellitus (T2DM) patients on sodium\u2010glucose cotransporter 2 inhibitors (SGLT2I) versus DPP4I.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This population\u2010based cohort study patients included patients who were diagnosed with T2DM and administered either SGLT2 or DPP4 inhibitors between 1 January 2015 and 31 December 2020 in public hospitals of Hong Kong.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study included 60,112 T2DM patients (mean baseline age: 62.1\u2009\u00b1\u200912.4\u2009years, male: 56.36%), of which 18,167 patients were SGLT2I users and 41,945 patients were dipeptidyl peptidase 4 inhibitor (DPP4I) users. Multivariable Cox regression found that SGLT2I use was associated with lower risks of all\u2010cause mortality (HR: 0.92; 95% CI: 0.84\u20130.99;\n                      <jats:italic>p<\/jats:italic>\n                      =\u20090.04), cancer\u2010related mortality (HR: 0.58; 95% CI: 0.42\u20130.80;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001) and new diagnoses of any cancer (HR: 0.70; 95% CI: 0.59\u20130.84;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001). SGLT2I use was associated with a lower risk of new\u2010onset breast cancer (HR: 0.51; 95% CI: 0.32\u20130.80;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001), but not of other malignancies. Subgroup analysis on the type of SGLT2I, dapagliflozin (HR: 0.78; 95% CI: 0.64\u20130.95;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and ertugliflozin (HR: 0.65; 95% CI: 0.43\u20130.98;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) use was associated with lower risks of new cancer diagnosis. Dapagliflozin use was also linked to lower risks of breast cancer (HR: 0.48; 95% CI: 0.27\u20130.83;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sodium\u2010glucose cotransporter 2 inhibitor use was associated with lower risks of all\u2010cause mortality, cancer\u2010related mortality and new\u2010onset overall cancer compared to DPP4I use after propensity score matching and multivariable adjustment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.5927","type":"journal-article","created":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T15:16:15Z","timestamp":1683386175000},"page":"12299-12315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Sodium\u2010glucose cotransporter 2 inhibitors versus dipeptidyl peptidase 4 inhibitors on new\u2010onset overall cancer in Type 2 diabetes mellitus: A population\u2010based study"],"prefix":"10.1002","volume":"12","author":[{"given":"Cheuk To","family":"Chung","sequence":"first","affiliation":[{"name":"Diabetes Research Unit Cardiovascular Analytics Group, China\u2010UK Collaboration  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishan","family":"Lakhani","sequence":"additional","affiliation":[{"name":"Diabetes Research Unit Cardiovascular Analytics Group, China\u2010UK Collaboration  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar Hou In","family":"Chou","sequence":"additional","affiliation":[{"name":"Diabetes Research Unit Cardiovascular Analytics Group, China\u2010UK Collaboration  Hong Kong China"},{"name":"Division of Clinical Pharmacology and Therapeutics, Department of Medicine, LKS Faculty of Medicine The University of Hong 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0482-0738","authenticated-orcid":false,"given":"Tong","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharen","family":"Lee","sequence":"additional","affiliation":[{"name":"Diabetes Research Unit Cardiovascular Analytics Group, China\u2010UK Collaboration  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingpeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Data Science City University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard Man Yung","family":"Cheung","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Therapeutics, Department of Medicine, LKS Faculty of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Tse","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University  Tianjin China"},{"name":"Kent and Medway Medical School University of Kent and Canterbury Christ Church University  Canterbury UK"},{"name":"School of Nursing and Health Studies Hong Kong Metropolitan University  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Diabetes Research Unit Cardiovascular Analytics Group, China\u2010UK Collaboration  Hong Kong 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