{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:11:12Z","timestamp":1792681872015,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with advanced hepatocellular carcinoma (HCC) and poor liver function lack effective systemic therapies. Low\u2010energy electromagnetic fields (EMFs) can influence cell biological processes via non\u2010thermal effects and may represent a new treatment option.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010site feasibility trial enrolled patients with advanced HCC, Child\u2010Pugh A and B, Eastern Cooperative Oncology Group 0\u20132. Patients underwent 90\u2010min amplitude\u2010modulated EMF exposure procedures every 2\u20134\u2009weeks, using the AutEMdev (Autem Therapeutics). Patients could also receive standard care. The primary endpoints were safety and the identification of hemodynamic variability patterns. Exploratory endpoints included health\u2010related quality of life (HRQoL), overall survival (OS). and objective response rate (ORR) using RECIST v1.1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010six patients with advanced HCC received 539 AutEMdev procedures (median follow\u2010up, 30\u2009months). No serious adverse events occurred during procedures. Self\u2010limiting grade 1 somnolence occurred in 78.7% of patients. Hemodynamic variability during EMF exposure was associated with specific amplitude\u2010modulation frequencies. HRQoL was maintained or improved among patients remaining on treatment. Median OS was 11.3\u2009months (95% confidence interval [CI]: 6.0, 16.6) overall (16.0\u2009months [95% CI: 4.4, 27.6] and 12.0\u2009months [6.4, 17.6] for combination therapy and monotherapy, respectively). ORR was 24.3% (32% and 17% for combination therapy and monotherapy, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AutEMdev EMF exposure has an excellent safety profile in patients with advanced HCC. Hemodynamic alterations at personalized frequencies may represent a surrogate of anti\u2010tumor efficacy. NCT01686412.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5944","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T12:50:33Z","timestamp":1684155033000},"page":"12402-12412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Low\u2010energy amplitude\u2010modulated electromagnetic field exposure: Feasibility study in patients with hepatocellular carcinoma"],"prefix":"10.1002","volume":"12","author":[{"given":"Fernanda","family":"Capareli","sequence":"first","affiliation":[{"name":"Oncology Department Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6651-3261","authenticated-orcid":false,"given":"Frederico","family":"Costa","sequence":"additional","affiliation":[{"name":"Oncology Department Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo Brazil"},{"name":"Autem Medical LLC  Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack A.","family":"Tuszynski","sequence":"additional","affiliation":[{"name":"Autem Medical LLC  Hanover New Hampshire USA"},{"name":"Division of Experimental Oncology, Department of Oncology Cross Cancer Institute, University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micelange C.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Oncology Department Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yone de C.","family":"Setogute","sequence":"additional","affiliation":[{"name":"Oncology Department Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo D.","family":"Lima","sequence":"additional","affiliation":[{"name":"Oncology Department Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Oncology Department Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Santos","sequence":"additional","affiliation":[{"name":"Oncology Department Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo Brazil"},{"name":"Oncology Department A. 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