{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:48:23Z","timestamp":1788281303630,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T00:00:00Z","timestamp":1681603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001073"],"award-info":[{"award-number":["UL1TR001073"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ethnic and racial disparities have recently been observed both in treatment\u2010related toxicities and rates of long\u2010lasting cure in acute lymphoblastic leukemia (ALL) and acute lymphoblastic lymphoma (ALLy), the most common pediatric malignancy. Despite significant improvements in overall survival in the recent past, a large number of children die from aggressive disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective cohort analysis of 274 pediatric ALL\/ALLy patients within Montefiore Health System from 2004 to 2021 to determine differences in all\u2010cause mortality within the Pediatric Hematologic Malignancies Cohort using Cox Proportional Hazard regression modeling, adjusted for age at diagnosis, race\/ethnicity, administration of intensive chemotherapy, preferred language, maximum glucose, and hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among our 274 patients, 132 were Hispanic, 54 Non\u2010Hispanic Black, and 25 Non\u2010Hispanic White, with 25 identified as \u201cNon\u2010Hispanic Other,\u201d including Asian, Arabic, and Other. Hispanic patients were 78% less likely to die (HR 0.22; 95% CI 0.07, 0.73) when compared with Non\u2010Hispanic Black individuals. Spanish speakers were 2.91 times more likely to die compared with those who spoke English (HR 2.91; 95% CI 1.08, 7.82). Among those English speakers, the diagnosis of hypertension and Hispanic ethnicity significantly impacted the risk of death, while these factors did not impact survival in Spanish speakers. High\u2010risk cytogenetics did not impact survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hispanic children with ALL\/ALLy have improved survival outcomes compared with Non\u2010Hispanic Blacks. Additionally, Spanish language preference was strongly associated with poorer survival, a novel finding that should be validated in future studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5951","type":"journal-article","created":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T20:38:05Z","timestamp":1681677485000},"page":"12827-12836","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of race\/ethnicity and language preferences on pediatric <scp>ALL<\/scp> survival outcomes"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2154-933X","authenticated-orcid":false,"given":"Meghan","family":"Davitt","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology, Oncology, Transplant and Cellular Therapy Children's Hospital at Montefiore, Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Gennarini","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Oncology, Transplant and Cellular Therapy Children's Hospital at Montefiore, Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Loeb","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Oncology, Transplant and Cellular Therapy Children's Hospital at Montefiore, Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Fazzari","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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