{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:06:22Z","timestamp":1757703982580,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971949"],"award-info":[{"award-number":["81971949"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030310649","2018A030313571","2023A1515030252"],"award-info":[{"award-number":["2017A030310649","2018A030313571","2023A1515030252"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Optimization of risk stratification is important for facilitating prognoses and therapeutic decisions regarding diffuse large B\u2010cell lymphoma (DLBCL). However, a simple and applicable prognostic tool is lacking for individuals with human immunodeficiency virus (HIV)\u2010related DLBCL in the era of combined antiretroviral therapy (cART).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective multicenter observational study included 147 HIV\u2010related DLBCL patients with histologically confirmed DLBCL from 2013 to 2020. The total group was divided into training (<jats:italic>n<\/jats:italic>\u2009=\u200978) and validation (<jats:italic>n<\/jats:italic>\u2009=\u200969) cohorts to derive the best prognostic score. Clinicopathological and characteristic biomarkers correlated with clinical outcomes were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Age, Ann Arbor stage, lactate dehydrogenase (LDH) ratio, bulky disease, and red blood cell distribution width (RDW) ratio retained robust independent correlations with overall survival (OS) in multivariate analysis. A new and practical prognostic model was generated and externally validated, classifying patients into three categories with significantly different survival rates. Moreover, the new index outperformed the International Prognostic Index (IPI) score (area under the curve values of 0.94 vs. 0.81 in the training cohort and 0.85 vs. 0.74 in the validation cohort, C\u2010indices of 0.80 vs. 0.70 in the training cohort and 0.74 vs. 0.70 in the validation cohort, and integrated discrimination improvement values of 0.203 in the training cohort and 0.175 in the validation cohort) and was better at defining intermediate\u2010 and high\u2010risk groups. The calibration curves performed satisfactorily for predicting 3\u2010year OS in the training and validation cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We developed and validated a simple and feasible prognostic model for patients with HIV\u2010related DLBCL that had more discriminative and predictive accuracy than the IPI score for risk stratification and individualized treatment in the cART era.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5957","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T05:20:37Z","timestamp":1682054437000},"page":"12470-12481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A promising prognostic model for predicting survival of patients with <scp>HIV<\/scp>\u2010related diffuse large B\u2010cell lymphoma in the <scp>cART<\/scp> era"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6960-3577","authenticated-orcid":false,"given":"Juanjuan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zixin","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanfang","family":"Qin","sequence":"additional","affiliation":[{"name":"Guangxi AIDS Diagnosis and Treatment Quality Control Center Longtan Hospital of Guangxi Zhuang Autonomous Region  Liuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangjing","family":"Ruan","sequence":"additional","affiliation":[{"name":"Guangxi AIDS Clinical Treatment Center The Fourth People's Hospital of Nanning  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Nanfang Hospital, Southern Medical University  Guangzhou China"},{"name":"Infectious Diseases Center Guangzhou Eighth People's Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiman","family":"Xie","sequence":"additional","affiliation":[{"name":"Guangxi AIDS 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