{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:37:56Z","timestamp":1789709876784,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T00:00:00Z","timestamp":1682726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immune checkpoint inhibitors (ICIs) have significantly improved survival in advanced melanoma but are associated with immune\u2010related adverse events (irAEs). This single center, cross\u2010sectional survey aimed to describe the long\u2010term symptom burden and impact on health\u2010related quality of life (HRQL) of advanced melanoma patients with sustained disease control following treatment with ICIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Advanced melanoma patients (stage IIB, III or IV, AJCCv8), treated with anti\u2010PD1\u2010based ICIs, who were off\u2010treatment and had at least 6\u2009months follow\u2010up from their last infusion with an ongoing response in the metastatic setting or no evidence of disease recurrence in the adjuvant setting. A paper\u2010based questionnaire, consisting of the EORTC QLQ\u2010C30, EORTC QLQ\u2010FA12, and the PRO\u2010CTCAE was administered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 90 participants, 61 (68%) completed the questionnaire; 40 received single\u2010agent anti\u2010PD1, and 21 anti\u2010PD1\/anti\u2010CTLA4. Thirty\u2010three (54%) were treated in the adjuvant setting. At the time of enrolment, 31 (51%) participants had active treatment for a previous irAE. Overall, 18\/61 (30%) participants reported long\u2010term symptoms and trouble in physical and emotional functioning. Physical fatigue was common and interfered with daily activities (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912, 20%). In the PRO\u2010CTCAE questionnaire, muscle ache (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912, 20%) and joint ache (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099, 15%) were commonly reported. Despite this, participants reported overall good health (6.00, range 2.00\u20137.00) and reasonable level of HRQL (6.00, range 3.00\u20137.00).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Melanoma survivors experience long\u2010term symptoms in physical and psychosocial HRQL domains after ICI treatment. These results underline the importance to address existing gaps in survivorship care, implement these findings in clinical practice and increase awareness for long\u2010term symptoms in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.5967","type":"journal-article","created":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T06:19:25Z","timestamp":1682749165000},"page":"12861-12873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Health\u2010related quality of life in survivors of advanced melanoma treated with\n                    <scp>anti\u2010PD1<\/scp>\n                    \u2010based immune checkpoint inhibitors"],"prefix":"10.1002","volume":"12","author":[{"given":"E. L.","family":"Looman","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital of Zurich  Zurich Switzerland"},{"name":"Department of Dermatology Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2940-006X","authenticated-orcid":false,"given":"P. F.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Zurich  Zurich Switzerland"},{"name":"Faculty of Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lai\u2010Kwon","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wakkee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Dummer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Zurich  Zurich Switzerland"},{"name":"Faculty of Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4529-3372","authenticated-orcid":false,"given":"F.","family":"Dimitriou","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Zurich  Zurich Switzerland"},{"name":"Faculty of Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.43"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1001"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02229"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.03.198"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2022.40.16_suppl.9522"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1802357"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709030"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00562-1"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1703481"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503093"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1509660"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.3923"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.10.001"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01440"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.0051"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2019-000260"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-019-00770-0"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04818-w"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21670"},{"key":"e_1_2_12_21_1","volume-title":"From Cancer Patient to Cancer Survivor: Lost in Transition","author":"Institute of Medicine and National Research Council","year":"2006"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.07.004"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-05168-3"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2020.1818823"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.251"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4587-1"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.09.033"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13122931"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5269062"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-020-02464-y"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2017.025114"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.5967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:43:43Z","timestamp":1697057023000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.5967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,29]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/cam4.5967"],"URL":"https:\/\/doi.org\/10.1002\/cam4.5967","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,29]]},"assertion":[{"value":"2022-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}