{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:46:11Z","timestamp":1780393571554,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T00:00:00Z","timestamp":1452816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"International Agency for Research on Cancer by the Ministries of Health, Labour and Welfare of Japan","award":["2012-02-21-01"],"award-info":[{"award-number":["2012-02-21-01"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Little is known about the incidence patterns of hematologic malignancies in Sub\u2010Saharan Africa, including South Africa. We estimated incidence rates of pathology\u2010confirmed adult cases of leukemia, myeloma and related diseases (myeloma), Hodgkin lymphoma (<jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>), and non\u2010Hodgkin lymphoma (<jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>) reported to the National Cancer Registry of South Africa (<jats:styled-content style=\"fixed-case\">NCR<\/jats:styled-content>) between 2000 and2006, by age, gender, and population group (Black, White, Coloured, Asian\/Indian). Gender\u2010specific age\u2010standardized rates were calculated overall and by population group and incidence rate ratios (<jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content>s) were estimated using Poisson regression models. Between 2000 and 2006, there were 14662 cases of leukemia, myeloma, <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content> reported to the registry. Incidence rates of reported hematologic malignancies were generally 20\u201350% higher among males than females. Our analyses suggested marked differences in the rates of reported hematologic malignancies by population group which were most pronounced when comparing the White versus Black population groups (<jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content>s ranging from 1.6 for myeloma to 3.8 for <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> for males and females combined). Challenges related to diagnosis and reporting of cancers may play a role in the patterns observed by population group while the set\u2010up of the <jats:styled-content style=\"fixed-case\">NCR<\/jats:styled-content> (pathology\u2010based) could lead to some degree of under\u2010ascertainment in all groups. This is the first country\u2010wide report of the incidence of hematologic malignancies in South Africa. Despite challenges, it is important to analyze and report available national cancer incidence data to raise awareness of the cancer burden and to characterize patterns by demographic characteristics so as ultimately to improve the provision of cancer\u2010related health care.<\/jats:p>","DOI":"10.1002\/cam4.597","type":"journal-article","created":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T21:50:49Z","timestamp":1452981049000},"page":"728-738","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Hematologic malignancies in South Africa 2000\u20132006: analysis of data reported to the National Cancer Registry"],"prefix":"10.1002","volume":"5","author":[{"given":"Sara J.","family":"Schonfeld","sequence":"first","affiliation":[{"name":"Section of Environment and Radiation International Agency for Research on Cancer (IARC)  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Erdmann","sequence":"additional","affiliation":[{"name":"Section of Environment and Radiation International Agency for Research on Cancer (IARC)  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey","family":"Wiggill","sequence":"additional","affiliation":[{"name":"Department of Haematology and Molecular Medicine National Health Laboratory Service  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Singh","sequence":"additional","affiliation":[{"name":"National Cancer Registry National Health Laboratory Service  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Kellett","sequence":"additional","affiliation":[{"name":"National Cancer Registry National Health Laboratory Service  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Babb","sequence":"additional","affiliation":[{"name":"National Cancer Registry National Health Laboratory Service  Johannesburg South Africa"},{"name":"Division of Human Genetics Faculty of Health Sciences University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Sch\u00fcz","sequence":"additional","affiliation":[{"name":"Section of Environment and Radiation International Agency for Research on Cancer (IARC)  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,15]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Ferlay J. I.Soerjomataram M.Ervik R.Dikshit S.\u00a0Eser C.Mathers et\u00a0al.GLOBOCAN 2012 v1.0 Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Available athttp:\/\/globocan.iarc.fr. 2013 (accessed on 15 February 2015)."},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1097\/QAI.0b013e3181bf5544","article-title":"Characterization of lymphomas in a high prevalence HIV setting","volume":"53","author":"Mantina H.","year":"2010","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/578163"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2012.07.012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2010.01.008"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2011.01.007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61050-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27454"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.31"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-347872"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2508"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.450"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-298760"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29308"},{"key":"e_1_2_8_16_1","unstructured":"Statistics South Africa.2007.General household survey: 2006. Statistical Release P0318. Pretoria."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.8858"},{"key":"e_1_2_8_18_1","volume-title":"International Classification of Diseases for Oncology","author":"Fritz A.","year":"2000"},{"key":"e_1_2_8_19_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow S. H.","year":"2008"},{"key":"e_1_2_8_20_1","unstructured":"Dorrington R. E..2013.Alternative South African midyear estimates. Centre for Actuarial Research Monograph 13. University of Cape Town; 2013."},{"key":"e_1_2_8_21_1","volume-title":"Cancer mortality for selected sites in 24 countries (1950\u201357)","author":"Segi M.","year":"1960"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-282632"},{"key":"e_1_2_8_24_1","unstructured":"Fast Stats: An interactive tool for access to SEER cancer statistics. 2015 Surveillance Research Program National Cancer Institute. Available athttp:\/\/seer.cancer.gov\/faststats. (accessed on 10 February 2015)"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr578"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195149616.003.0045"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195149616.003.0046"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195149616.003.0044"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgu013"},{"key":"e_1_2_8_30_1","first-page":"329","article-title":"The role of private hospitals in South Africa. Part I. current trends","volume":"82","author":"Broomberg J.","year":"1992","journal-title":"S. Afr. Med. J."},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1405012"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60951-X"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28861"},{"key":"e_1_2_8_34_1","volume-title":"South African National HIV Prevalence, Incidence and Behaviour Survey, 2012","author":"Shisana O.","year":"2014"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2013.07.020"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-9378-6-16"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31820bb06a"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.597","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.597","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.597","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:50:43Z","timestamp":1696607443000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,15]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/cam4.597"],"URL":"https:\/\/doi.org\/10.1002\/cam4.597","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,15]]},"assertion":[{"value":"2015-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}