{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:47:03Z","timestamp":1778809623767,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006436","name":"Celgene","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018071","name":"Knight Cancer Institute, Oregon Health and Science University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neoadjuvant treatment with nab\u2010paclitaxel and gemcitabine for potentially operable pancreatic adenocarcinoma has not been well studied in a prospective interventional trial and could down\u2010stage tumors to achieve negative surgical margins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010arm, open\u2010label phase 2 trial (NCT02427841) enrolled patients with pancreatic adenocarcinoma deemed to be borderline resectable or clinically node\u2010positive from March 17, 2016 to October 5, 2019. Patients received preoperative gemcitabine 1000\u2009mg\/m<jats:sup>2<\/jats:sup> and nab\u2010paclitaxel 125\u2009mg\/m<jats:sup>2<\/jats:sup> on Days 1, 8, 15, every 28\u2009days for two cycles followed by chemoradiation with 50.4\u2009Gy intensity\u2010modulated radiation over 28 fractions with concurrent fluoropyrimidine chemotherapy. After definitive resection, patients received four additional cycles of gemcitabine and nab\u2010paclitaxel. The primary endpoint was R0 resection rate. Other endpoints included treatment completion rate, resection rate, radiographic response rate, survival, and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen patients were enrolled, with the majority having head of pancreas primary tumors, both arterial and venous vasculature involvement, and clinically positive nodes on imaging. Among them, 11 (58%) underwent definitive resection and eight of 19 (42%) achieved R0 resection. Disease progression and functional decline were primary reasons for deferring surgical resection after neoadjuvant treatment. Pathologic near\u2010complete response was observed in two of 11 (18%) resection specimens. Among the 19 patients, the 12\u2010month progression\u2010free survival was 58%, and 12\u2010month overall survival was 79%. Common adverse events were alopecia, nausea, vomiting, fatigue, myalgia, peripheral neuropathy, rash, and neutropenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Gemcitabine and nab\u2010paclitaxel followed by long\u2010course chemoradiation represents a feasible neoadjuvant treatment strategy for borderline resectable or node\u2010positive pancreatic cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5971","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T07:38:16Z","timestamp":1683099496000},"page":"12986-12995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Phase 2 study of preoperative chemotherapy with nab\u2010paclitaxel and gemcitabine followed by chemoradiation for borderline resectable or node\u2010positive pancreatic ductal adenocarcinoma"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3035-4478","authenticated-orcid":false,"given":"Emerson Y.","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Hematology and Medical Oncology Oregon Health &amp; 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Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Lanciault","sequence":"additional","affiliation":[{"name":"Providence Cancer Institute  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4690-4948","authenticated-orcid":false,"given":"Aaron","family":"Grossberg","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth G.","family":"Bensch","sequence":"additional","affiliation":[{"name":"Portland VA Medical Center  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Maynard","sequence":"additional","affiliation":[{"name":"Portland VA Medical Center  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric C.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Oregon Health &amp; 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