{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:22:20Z","timestamp":1790054540453,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T00:00:00Z","timestamp":1683331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["IIllSN\u20102612013000111"],"award-info":[{"award-number":["IIllSN\u20102612013000111"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA022453"],"award-info":[{"award-number":["P30 CA022453"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA200864"],"award-info":[{"award-number":["R01 CA200864"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01 CA199240"],"award-info":[{"award-number":["U01 CA199240"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Endometrial cancer (EC) is the most common gynecologic malignancy in developed countries, with overall incidence increasing, particularly high\u2010grade disease. There is sparse information regarding quality of life (QOL) in EC survivors with a focus on grade of disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 259 women with EC diagnosed between 2016 and 2020 were identified via the Metropolitan Detroit Cancer Surveillance System and consented to enroll in the Detroit Research on Cancer Survivors cohort study (if African American, <jats:italic>n<\/jats:italic>\u2009=\u2009138) or completed the baseline interview (if non\u2010Hispanic white, <jats:italic>n<\/jats:italic>\u2009=\u2009121). Each respondent provided information about their health history, educational attainment, health behaviors, and demographics. The Functional Assessment of Cancer Therapy\u2010General (FACT\u2010G) and Endometrial\u2010specific (FACT\u2010En) were used to assess QOL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women diagnosed with high\u2010grade (<jats:italic>n<\/jats:italic>\u2009=\u2009112) and low\u2010grade (<jats:italic>n<\/jats:italic>\u2009=\u2009147) EC participated in this study. EC survivors with high\u2010grade disease reported significantly lower QOL compared to survivors with low\u2010grade disease (85 vs. 91, respectively, <jats:italic>p<\/jats:italic> value\u2009=\u20090.025) as assessed by the FACT\u2010G. This difference was driven by lower physical and functional subscales among women with high\u2010grade disease compared to those with low\u2010grade disease (<jats:italic>p<\/jats:italic> value\u2009=\u20090.016 and <jats:italic>p<\/jats:italic>\u2009=\u20090.028, respectively). Interestingly, EC\u2010specific QOL measures, as assessed by the FACT\u2010En, did not differ by grade.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Grade of disease impacts QOL in EC survivors, as well as socioeconomic, psychological, and physical factors. Most of these factors are amenable to interventions and should be assessed in patients after an EC diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5987","type":"journal-article","created":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T19:19:57Z","timestamp":1683400797000},"page":"13675-13686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Quality of life in endometrial cancer survivors by grade of disease"],"prefix":"10.1002","volume":"12","author":[{"given":"K.","family":"Banning","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Fucinari","sequence":"additional","affiliation":[{"name":"Department of Oncology Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fielder","sequence":"additional","affiliation":[{"name":"Department of Oncology Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Ruterbusch","sequence":"additional","affiliation":[{"name":"Department of Oncology Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Beebe\u2010Dimmer","sequence":"additional","affiliation":[{"name":"Department of Oncology Wayne State University School of Medicine  Detroit Michigan USA"},{"name":"Population Studies and Disparities Research Program The Barbara Ann Karmanos Cancer Institute  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. G.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Oncology Wayne State University School of Medicine  Detroit Michigan USA"},{"name":"Population Studies and Disparities Research Program The Barbara Ann Karmanos Cancer Institute  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Wallbillich","sequence":"additional","affiliation":[{"name":"Department of Oncology Wayne State University School of Medicine  Detroit Michigan USA"},{"name":"Molecular Therapeutics Program The Barbara Ann Karmanos Cancer Institute  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0312-1601","authenticated-orcid":false,"given":"M. L.","family":"Cote","sequence":"additional","affiliation":[{"name":"Department of Oncology Wayne State University School of Medicine  Detroit Michigan USA"},{"name":"Population Studies and Disparities Research Program The Barbara Ann Karmanos Cancer Institute  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx214"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00151"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.05.024"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0316"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21565"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.12.010"},{"key":"e_1_2_9_9_1","volume-title":"SEER Cancer Statistics Review 1975\u20102018","author":"Howlader N","year":"2021"},{"key":"e_1_2_9_10_1","volume-title":"Measuring Healthy Days: Population Assessment of Health\u2010Related Quality of Life","author":"Centers for Disease Control and Prevention","year":"2000"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2022.03.012"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-020-00869-9"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.11.007"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32725"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.3.570"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-1-79"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02310555"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0163278705275340"},{"key":"e_1_2_9_20_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2017"},{"key":"e_1_2_9_21_1","unstructured":"HuangHQ FiliaciVL CellaD.Reliability and validity of the trial outcome index (TOI\u2010EN) in endometrial cancer. 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