{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:42:14Z","timestamp":1788176534734,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T00:00:00Z","timestamp":1683331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750"],"award-info":[{"award-number":["320.6750"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mantle cell lymphoma (MCL) is an uncommon heterogeneous subtype of B cell non\u2010Hodgkin lymphoma, and clinical features in MCL appear regional characteristics. MCL treatment opinions are not uniform between countries or regions within Asia and China, and Asian patient\u2010specific data for MCL treatment are fewer. The study aims to explore the clinical characteristics, treatment patterns and prognosis of MCL patients in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 805 patients diagnosed with MCL between April 1999 and December 2019 at 19 comprehensive hospitals in China were included in this retrospective analysis. Kaplan\u2010Meier method coupled with the log\u2010rank test was used for univariate analysis, and COX proportional hazards model was used for multivariate analysis (MVA). <jats:italic>p<\/jats:italic> &lt; 0.05 was consided statistically significant. All outputs were produced using R version 4.1.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age of the cohort was 60.0 years with a male\u2010to\u2010female ratio of 3.36:1. Five\u2010year progression\u2010free survival (PFS) and overall survival (OS) rates were 30.9% and 65.0%, respectively. High\u2010intermediate\/high\u2010risk group according to MIPI\u2010c, without high\u2010dose cytarabine, lack of Auto\u2010SCT as consolidation and maintenance treatment and SD\/PD in initial treatment remained statistically relevant to poor PFS on MVA, and ki67 \u226550%, B symptoms, high\u2010intermediate\/high risk group according to MIPI\u2010c, without high\u2010dose cytarabine, lack of maintenance treatment, SD\/PD in initial treatment and relapse\/refractory state were independently associated with poorer OS on MVA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>First\u2010line high dose cytarabine exposure, auto\u2010SCT as consolidation therapy obtained survival benefits in Chinese population. Our study further confirmed the value of maintenance treatment and explored the application of new drug treatment and bendamustine in R\/R MCL patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6009","type":"journal-article","created":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T19:30:08Z","timestamp":1683401408000},"page":"13204-13216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Real\u2010world treatment and outcome patterns of patients with mantle cell lymphoma in China: A large, multicenter retrospective analysis"],"prefix":"10.1002","volume":"12","author":[{"given":"Ping","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Hematology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5447-3282","authenticated-orcid":false,"given":"Qing\u2010qing","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9489-5965","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo\u2010zi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology Beijing Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu\u2010hua","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7935-6194","authenticated-orcid":false,"given":"Yu\u2010jun","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu\u2010bin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Senior Department of Hematology The 5th Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010wen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Beijing Tongren Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen\u2010ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010rong","family":"Huang","sequence":"additional","affiliation":[{"name":"Senior Department of Hematology The 5th Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010hong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Beijing Tsinghua Changgung Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010zheng","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jilin Cancer Hospital  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010lan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Baotou Cancer Hospital  Baotou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010ye","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Liaoning Cancer Hospital &amp; Institute  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai\u2010chun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Lymphatic Medicine Harbin Medical University Cancer Hospital  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4958-2489","authenticated-orcid":false,"given":"Hong\u2010mei","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21357"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-282632"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25487"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-559930"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-189977"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02287"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-015-1840-6"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24797"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-03-791392"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00855-9"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2461"},{"issue":"4","key":"e_1_2_11_13_1","first-page":"218","article-title":"Prevalence of lymphoma subtypes in Shanxi according to latest WHO classification","volume":"35","author":"Wang JF","year":"2006","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012120"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0253-2727.2016.09.002"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00690"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2019.1605511"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2020.06.005"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.20056"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17419"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-521898"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2860"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2596"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17513"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-147025"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14241"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-370320"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00739-X"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.1825"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt070"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08958.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13796"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505237"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-07-859769"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2020-0794"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(21)00195-2"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31328"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-04-77973638"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-022-01899-w"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1701769"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01294"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0023-2"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.205229"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00884-4"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(18)30018-8"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1715519"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00559-8"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16739"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008727"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17363"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-537555"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-01013-3"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.209015"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004765"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:04:13Z","timestamp":1699362253000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,6]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/cam4.6009"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6009","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,6]]},"assertion":[{"value":"2022-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}