{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:22:57Z","timestamp":1792174977475,"version":"4.4.0"},"reference-count":131,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011659","name":"L\u00e9ka\u0159sk\u00e1 fakulta, Masarykova univerzita","doi-asserted-by":"publisher","award":["MUNI\/A\/1224\/2022"],"award-info":[{"award-number":["MUNI\/A\/1224\/2022"]}],"id":[{"id":"10.13039\/501100011659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pheochromocytomas (PCCs) are rare neuroendocrine tumors derived from the chromaffin cells of the adrenal medulla. When these tumors have an extra\u2010adrenal location, they are called paragangliomas (PGLs) and arise from sympathetic and parasympathetic ganglia, particularly of the para\u2010aortic location. Up to 25% of PCCs\/PGLs are associated with inherited genetic disorders. The majority of PCCs\/PGLs exhibit indolent behavior. However, according to their affiliation to molecular clusters based on underlying genetic aberrations, their tumorigenesis, location, clinical symptomatology, and potential to metastasize are heterogenous. Thus, PCCs\/PGLs are often associated with diagnostic difficulties. In recent years, extensive research revealed a broad genetic background and multiple signaling pathways leading to tumor development. Along with this, the diagnostic and therapeutic options were also expanded. In this review, we focus on the current knowledge and recent advancements in the diagnosis and treatment of PCCs\/PGLs with respect to the underlying gene alterations while also discussing future perspectives in this field.<\/jats:p>","DOI":"10.1002\/cam4.6010","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T14:04:55Z","timestamp":1683295495000},"page":"13942-13957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Management of pheochromocytomas and paragangliomas: Review of current diagnosis and treatment options"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4433-5326","authenticated-orcid":false,"given":"Michal","family":"Eid","sequence":"first","affiliation":[{"name":"Department of Hematology, Oncology and Internal Medicine, University Hospital Brno Faculty of Medicine, Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4321-401X","authenticated-orcid":false,"given":"Jakub","family":"Foukal","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, University Hospital Brno Faculty of Medicine, Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1925-2892","authenticated-orcid":false,"given":"Dana","family":"Sochorov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital Brno Faculty of Medicine, Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4536-1155","authenticated-orcid":false,"given":"\u0160t\u011bp\u00e1n","family":"Tu\u010dek","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Internal Medicine, University Hospital Brno Faculty of Medicine, Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Star\u00fd","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Internal Medicine, University Hospital Brno Faculty of Medicine, Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4187-388X","authenticated-orcid":false,"given":"Zden\u011bk","family":"Kala","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital Brno Faculty of Medicine, Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0567-9887","authenticated-orcid":false,"given":"Ji\u0159\u00ed","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Internal Medicine, University Hospital Brno Faculty of Medicine, Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6825-0960","authenticated-orcid":false,"given":"Radim","family":"N\u011bme\u010dek","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute Faculty of Medicine, Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-9736","authenticated-orcid":false,"given":"Jan","family":"Trna","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute Faculty of Medicine, Masaryk University  Brno Czech Republic"},{"name":"Department of Gastroenterology and Digestive Endoscopy Masaryk Memorial Cancer Institute  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2985-8759","authenticated-orcid":false,"given":"Lum\u00edr","family":"Kunovsk\u00fd","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital Brno Faculty of Medicine, Masaryk University  Brno Czech Republic"},{"name":"Department of Gastroenterology and Digestive Endoscopy Masaryk Memorial Cancer Institute  Brno Czech Republic"},{"name":"2nd Department of Internal Medicine \u2013 Gastroenterology and Geriatrics, University Hospital Olomouc Faculty of Medicine and Dentistry, Palacky University Olomouc  Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"issue":"12","key":"e_1_2_14_2_1","first-page":"802","article-title":"Occurrence of pheochromocytoma in Rochester, Minnesota, 1950 through 1979","volume":"58","author":"Beard CM","year":"1983","journal-title":"Mayo Clin Proc"},{"issue":"6","key":"e_1_2_14_3_1","first-page":"354","article-title":"Prevalence of clinically unsuspected pheochromocytoma. Review of a 50\u2010year autopsy series","volume":"56","author":"Sutton MG","year":"1981","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.2.6372"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-015-0001-x"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP15618.OR"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-020-02332-2"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23352"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-3829"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-08220-3"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2017.32.2.152"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.932789"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0456"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0000000000000141"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1128139"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1500681"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-015-1738-z"},{"issue":"10","key":"e_1_2_14_18_1","first-page":"349","article-title":"Pheochromocytoma associated with polycythemia: case report","volume":"48","author":"Rezkalla MA","year":"1995","journal-title":"S D J Med"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/js.2018-00086"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1498"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0803-4"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2018.291369"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1093"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0756"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.00838"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.153320"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11101505"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.4149\/endo_2011_02_65"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11040586"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000518873"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0727"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-72-2-455"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11071018"},{"key":"e_1_2_14_34_1","first-page":"209","article-title":"Treatment of malignant pheochromocytoma with a new radiopharmaceutical","volume":"96","author":"Sisson J","year":"1983","journal-title":"Trans Assoc Am Physicians"},{"issue":"2","key":"e_1_2_14_35_1","first-page":"155","article-title":"Imaging the adrenal medulla with an I\u2010131\u2010labeled antiadrenergic agent","volume":"20","author":"Wieland DM","year":"1979","journal-title":"J Nucl Med"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0333"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04398-1"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000381458"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11060847"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.211706"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-012-2215-8"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2017-00062"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1648608"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-4375"},{"key":"e_1_2_14_45_1","first-page":"S21","article-title":"Hereditary pheochromocytoma and paraganglioma","volume":"25","author":"Musil Z","year":"2012","journal-title":"Klin Onkol"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.543246"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2020.101416"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2017.04.009"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2018-105714"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr324"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11111239"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnab019"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.01.001"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa502"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2012.07.001"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-20-0992"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.07.016"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1946"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11020225"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200205000-00002"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-13-0494"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa608"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa982"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-017-9484-5"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4231"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-11-0308"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/life11111179"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz188"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4519-y"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1053\/jcan.2002.124150"},{"issue":"4","key":"e_1_2_14_71_1","first-page":"190","article-title":"Pheochromocytoma: a review on preoperative treatment with phenoxybenzamine or doxazosin","volume":"72","author":"Zee PA","year":"2014","journal-title":"Neth J Med"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.0032"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1720"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002438"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2018.11.018"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-020-00824-6"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2021.04.001"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-013-3169-z"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-008-0264-7"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.05.011"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs-2019-ra-05"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-019-1649-x"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2012.12.007"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-021-02312-8"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001792"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10744"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815605323"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1148\/rycan.210088"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2008.9.1.87"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.4174\/astr.2020.99.6.315"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6468"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2022.01.110"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2013.04.027"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002195"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5739-5"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-00992"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26577"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1398"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.34.6353"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1353.038"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-011-9545-3"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1907"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00166"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2017.11.002"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11020195"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.186833"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-02030"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.217463"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0113"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8070952"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-00816"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24553"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12542"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23812"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19951015)76:8<1476::aid-cncr2820760827>3.0.co;2-9"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-013-0133-2"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-018-0579-4"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28913"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.13995.1"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.233"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0474-x"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-017-0643-0"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.33.7_suppl.457"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvac044"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1359-5"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27675"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00719"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2103425"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11040436"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12020345"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12082307"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10010088"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T19:39:07Z","timestamp":1692301147000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,5]]},"references-count":131,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/cam4.6010"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6010","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,5]]},"assertion":[{"value":"2022-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}