{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T23:01:47Z","timestamp":1762642907938,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T00:00:00Z","timestamp":1686960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although thymic squamous cell carcinoma (TSCC) is among the most prevalent forms of thymic carcinoma, there are relatively few studies on this tumor type, and its staging, optimal treatment strategies, and relevant prognostic factors remain controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study analyzed 79 patients diagnosed with TSCC between January 2008 and January 2021. Kaplan\u2013Meier curves and Cox univariate and multivariate regression analyses were used to explore factors associated with overall survival (OS) and progression\u2010free survival (PFS) in the overall patient cohort and patient subgroups stratified according to the TNM stage. Time\u2010dependent receiver operating characteristic (ROC) analyses were used to compare the TNM and Masaoka systems as predictors of patient prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 5\u2010 and 10\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> rates in this study were 65.5% and 49.4%, respectively, with corresponding 5\u2010 and 10\u2010year <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> rates of 52.3% and 37.9%. Survival outcomes were better for patients with early\u2010stage disease (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and patients that underwent surgical treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Neither extent of resection (<jats:italic>p<\/jats:italic>\u2009=\u20090.820) nor the surgical approach (<jats:italic>p<\/jats:italic>\u2009=\u20090.444) influenced patient survival. In individuals with advanced disease, all forms of adjuvant therapy including radiotherapy (<jats:italic>p<\/jats:italic>\u2009=\u20090.021), chemotherapy (<jats:italic>p<\/jats:italic>\u2009=\u20090.035), and chemoradiation (<jats:italic>p<\/jats:italic>\u2009=\u20090.01) significantly improved patient <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>, but only adjuvant chemoradiotherapy improved patient <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> (<jats:italic>p<\/jats:italic>\u2009=\u20090.035). When predicting the patient survival outcomes, the <jats:styled-content style=\"fixed-case\">TNM<\/jats:styled-content> system was slightly superior to the Masaoka system (area under the <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve [<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>] at 5\u2009years: <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>, 0.742 vs. 0.723; <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>, 0.846 vs. 0.816).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TSCC is an orphan malignancy with a poor prognosis. TNM staging may be superior to Masaoka staging as a predictor of TSCC patient prognosis. Surgery is the mainstay of TSCC treatment. Video\u2010assisted thoracoscopy (VATS) should be considered for selected patients. Multimodal therapy was associated with excellent results for patients with advanced TNM stage, particularly when surgery was accompanied by adjuvant chemoradiation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6049","type":"journal-article","created":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T08:40:27Z","timestamp":1686991227000},"page":"14025-14036","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identification of predictors of long\u2010term survival and prognostic outcomes in thymic squamous cell carcinoma: A real\u2010world study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1922-0508","authenticated-orcid":false,"given":"Meng\u2010Xin","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing 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