{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:37:07Z","timestamp":1787161027799,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Few studies have focused on high\u2010flow nasal cannula (HFNC) usage in the last few weeks of life. The aim of this study was to identify the status of HFNC use in patients with cancer at the end of life and the relevant clinical factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective cohort study in a tertiary hospital in the Republic of Korea. Among patients with cancer who died between 2018 and 2020, those who initiated HFNC within 14\u2009days before death were included. Patients were categorized based on the time from HFNC initiation to death as imminent (&lt;4\u2009days) and non\u2010imminent (\u22654\u2009days).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 2191 deceased patients with terminal cancer, 329 (15.0%) were analyzed. The median age of the patients was 66\u2009years, and 62.9% were male. The leading cause of respiratory failure was pneumonia (70.2%), followed by pleural effusion (30.7%) and aggravation of lung neoplasms (18.8%). Most patients were conscious (79.3%) and had resting dyspnea (76.3%) at HFNC initiation. Patients received HFNC therapy for a mean of 3.4\u2009days in the last 2\u2009weeks of life, and 62.6% initiated it within 4\u2009days before death. Furthermore, female sex, no palliative care consultation, no advance statements in person on life\u2010sustaining treatment, and no resting dyspnea were independently associated with the imminent use of HFNC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Many patients with cancer started HFNC therapy at the point of imminent death. However, efforts toward goal\u2010directed use of HFNC at the end\u2010of\u2010life stage are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.6060","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:26:09Z","timestamp":1683764769000},"page":"14612-14622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Use of high\u2010flow nasal cannula oxygen therapy for patients with terminal cancer at the end of life"],"prefix":"10.1002","volume":"12","author":[{"given":"Jung Sun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Chungnam National University Sejong Hospital Sejong Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongmi","family":"Shin","sequence":"additional","affiliation":[{"name":"Public Healthcare Center Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Palliative Care and Clinical Ethics Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Public Healthcare Center Seoul National University Hospital Seoul Korea"},{"name":"Department of Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7473-1082","authenticated-orcid":false,"given":"Shin Hye","family":"Yoo","sequence":"additional","affiliation":[{"name":"Center for Palliative Care and Clinical Ethics Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8196-4247","authenticated-orcid":false,"given":"Bhumsuk","family":"Keam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Seog","family":"Heo","sequence":"additional","affiliation":[{"name":"Patient\u2010Centered Clinical Research Coordinating Center National Evidence\u2010based Healthcare Collaborating Agency Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2005.06.007"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.7874"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201111-2042ST"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-684X-10-15"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03465"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pulmoe.2021.08.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70009-3"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2019.09.009"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13622"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-022-07330-w"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.06618"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzi061"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2013-0457"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29048"},{"key":"e_1_2_10_17_1","unstructured":"National Comprehensive Cancer Network.Adult Cancer Pain (Version 2.2022). 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