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We evaluated patient demographics, tumor characteristics, and treatment variables in the first 392 patients in a prospective study assessing radiation\u2010induced skin toxicity. Logistic regression analyses were conducted to evaluate potential predictors of skin toxicity. The study consists of 59 non\u2010Hispanic whites (<jats:styled-content style=\"fixed-case\">NHW<\/jats:styled-content>; 15%), 241 Hispanic Whites (<jats:styled-content style=\"fixed-case\">HW<\/jats:styled-content>; 62%), 79 black or African Americans (<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>; 20%), and 13 others (3%). Overall, 48% developed grade 0\u20131 skin toxicity, 49.8% grade 2, and 2.2% grade 3 by the National Cancer Institute's Common Toxicity Criteria for Adverse Events (<jats:styled-content style=\"fixed-case\">CTCAE<\/jats:styled-content>) scale. Twenty\u2010one percent developed moist desquamation. In multivariate analysis, higher body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>;<jats:styled-content style=\"fixed-case\"> OR<\/jats:styled-content>\u00a0=\u00a02.09; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.15, 3.82), higher disease stage (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.82; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.06, 3.11), <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u2010positive\/<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\u2010negative status (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.74; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.26, 5.98), and conventionally fractionated regimens (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a03.25; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.76, 6.01) were significantly associated with higher skin toxicity grade after adjustment for age, race, ethnicity, <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> status, and breast volume. <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> specifically predicted for moist desquamation, but not degree of erythema. In this racially and ethnically diverse cohort of breast cancer patients receiving radiation to the intact breast, risk factors including <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, disease stage, and conventionally fractionated radiation predicted for higher skin toxicity grade, whereas age, race, ethnicity, and breast volume did not. <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> specifically predicted for moist desquamation, suggesting that preventive measures to address this particular outcome should be investigated.<\/jats:p>","DOI":"10.1002\/cam4.608","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T06:47:42Z","timestamp":1452754062000},"page":"454-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Prospective evaluation of radiation\u2010induced skin toxicity in a race\/ethnically diverse breast cancer population"],"prefix":"10.1002","volume":"5","author":[{"given":"Jean L.","family":"Wright","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology and Molecular Radiation Sciences Johns Hopkins University  Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane","family":"Takita","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Miami School of Medicine  Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isildinha M.","family":"Reis","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of Miami School of Medicine  Miami Florida"},{"name":"Sylvester Comprehensive Cancer Center University of Miami School of Medicine  Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center University of Miami School of Medicine  Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunkyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of Miami School of Medicine  Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar L.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of Miami School of Medicine  Miami Florida"},{"name":"Sylvester Comprehensive Cancer Center University of Miami School of Medicine  Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer J.","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of Miami School of Medicine  Miami Florida"},{"name":"Sylvester Comprehensive Cancer Center University of Miami School of Medicine  Miami 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