{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:08:39Z","timestamp":1791216519208,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019331","name":"Henan Medical Science and Technique Foundation","doi-asserted-by":"publisher","award":["SBGJ202002068"],"award-info":[{"award-number":["SBGJ202002068"]}],"id":[{"id":"10.13039\/501100019331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2018YFC1705102"],"award-info":[{"award-number":["2018YFC1705102"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To improve the understanding of special types of tumors, we summarized and analyzed the clinicopathological features and prognostic factors of SMARCA4\u2010deficient non\u2010small cell lung cancer (SMARCA4\u2010dNSCLC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We selected 105 patients with SMARCA4\u2010dNSCLC and 221 patients with SMARCA4\u2010intact non\u2010small cell lung cancer (SMARCA4\u2010iNSCLC) by performing immunohistochemical analysis of 1520 NSCLC samples, and we assessed the patients' clinicopathological features and survival state.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      (1) SMARCA4\u2010dNSCLC was significantly associated with older age, male sex, smoking history, larger invasive tumor size, higher tumor proliferation index (Ki\u201067), more adrenal metastases, more lymph node metastases, and few\n                      <jats:italic>EGFR<\/jats:italic>\n                      mutations (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The tumors were mostly negative for thyroid transcription factor\u20101 (TTF\u20101), CD34, and p40 and positive for cytokeratin 7 (CK7) in immunohistochemistry (IHC). Nineteen SMARCA4\u2010dNSCLC patients mostly had\n                      <jats:italic>TP53<\/jats:italic>\n                      ,\n                      <jats:italic>SMARCA4<\/jats:italic>\n                      , and\n                      <jats:italic>LRP1B<\/jats:italic>\n                      mutations, and 48% of them had\n                      <jats:italic>SMARCA4<\/jats:italic>\n                      frameshift mutations. SMARCA4\u2010dNSCLC patients have a worse prognosis than SMARCA4\u2010iNSCLC patients (HR: 0.27; 95% CI: 0.17\u20130.45). The overall survival (OS) of patients with stage III SMARCA4\u2010dNSCLC was worse than that of patients with SMARCA4\u2010iNSCLC, and the OS of stage IV SMARCA4\u2010dNSCLC patients was also worse than that of SMARCA4\u2010iNSCLC patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). (2) Multivariate regression analysis showed that sex (HR: 4.12; 95% CI: 1.03\u201316.39) and smoking history (HR: 2.29; 95% CI: 1.04\u20135.02) had significant effects on the survival time of SMARCA4\u2010dNSCLC patients. In SMARCA4\u2010dNSCLC patients without distant metastases (stage I\u2013III), patients with stage N2 or N3 lymph node metastases (HR: 6.35; 95% CI: 1.07\u201337.47) had a poor prognosis. Among patients with SMARCA4\u2010dNSCLC who were treated and had distant metastases (stage IV), male patients and patients treated with immunotherapy combined with chemotherapy showed a longer median overall survival (mOS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SMARCA4\u2010dNSCLC has unique clinicopathological features and a shorter survival prognosis than SMARCA4\u2010iNSCLC. The efficacy of immunotherapy combined with chemotherapy needs to be observed for longer periods.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.6083","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T08:10:20Z","timestamp":1684138220000},"page":"14171-14182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Clinical characteristics and prognostic analysis of\n                    <scp>SMARCA4<\/scp>\n                    \u2010deficient non\u2010small cell lung cancer"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3308-9596","authenticated-orcid":false,"given":"Xiyue","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  Zhengzhou 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