{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:37:19Z","timestamp":1790779039341,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Taiwan has one of the highest incidences of upper tract urothelial cancer (UTUC) worldwide, especially in women; however, no nationwide, long\u2010term follow\u2010up study has evaluated this.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated the incidence of UTUC in Taiwan using data from the national population\u2010based Taiwan Cancer Registry database (1985\u20132019). We divided the birth cohort into nine 5\u2010year age groups and calculated the age\u2010specific incidence for these groups according to the corresponding birth years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average annual percent change in the incidence of renal pelvis cancer from 1985 to 2019 showed sex\u2010specific differences, with 3.5% and 5.3% increases in the incidences in men and women, respectively. The age\u2010specific incidence rate for renal pelvis cancer among women showed a gradual increase in the group with older women as well as an increase over time in each age group. The results of a birth cohort analysis revealed that younger cohorts had higher incidence rates of renal pelvis cancer than older cohorts did.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We demonstrated that the incidence of UTUC is unusually high among older Taiwanese women and that younger cohorts have a high risk of UTUC than older cohorts.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6084","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T12:43:56Z","timestamp":1688215436000},"page":"15350-15357","source":"Crossref","is-referenced-by-count":19,"title":["Trends and sex\u2010specific incidence of upper urinary tract cancer in Taiwan: A birth cohort study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4664-0877","authenticated-orcid":false,"given":"Yu\u2010Hsuan","family":"Chang","sequence":"first","affiliation":[{"name":"School of Medicine Fu\u2010Jen Catholic University  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7271-6070","authenticated-orcid":false,"given":"Wan\u2010Lun","family":"Hsu","sequence":"additional","affiliation":[{"name":"Data Science Center, College of Medicine Fu\u2010Jen Catholic University  New Taipei City Taiwan"},{"name":"Master Program of Big Data Analysis in Biomedicine, College of Medicine Fu\u2010Jen Catholic University  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0308-7653","authenticated-orcid":false,"given":"Yu\u2010Kwang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of General Surgery National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1330-5319","authenticated-orcid":false,"given":"Chun\u2010Ju","family":"Chiang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6330-6830","authenticated-orcid":false,"given":"Ya\u2010Wen","family":"Yang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3192-3356","authenticated-orcid":false,"given":"San\u2010Lin","family":"You","sequence":"additional","affiliation":[{"name":"School of Medicine Fu\u2010Jen Catholic University  New Taipei City Taiwan"},{"name":"Data Science Center, College of Medicine Fu\u2010Jen Catholic University  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1007-3003","authenticated-orcid":false,"given":"Yong\u2010Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Data Science Center, College of Medicine Fu\u2010Jen Catholic University  New Taipei City Taiwan"},{"name":"Master Program of Big Data Analysis in Biomedicine, College of Medicine Fu\u2010Jen Catholic University  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0552-372X","authenticated-orcid":false,"given":"Tai\u2010Shuan","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00230-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56394-y"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67019-X"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08889.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13232"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-020-03576-3"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-016-1928-x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14731"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0000000000000596"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-010-0594-7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(03)00079-9"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13376"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-12-1386"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003255"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2019.01.012"},{"key":"e_1_2_10_18_1","unstructured":"Health Promotion Administration Ministry of Health and Welfare.Cancer Registry Annual Report 2019 Taiwan. Taiwan Republic of China: Health Promotion Administration Ministry of Health and Welfare2021."},{"key":"e_1_2_10_19_1","volume-title":"International Classification of Diseases for Oncology (ICD\u2010O)","author":"Fritz A","year":"2000"},{"key":"e_1_2_10_20_1","volume-title":"Age Standardization of Rates: A New WHO Standard","author":"Ahmad OB","year":"2001"},{"key":"e_1_2_10_21_1","first-page":"1013","volume-title":"International Association of Cancer R. Cancer Incidence in Five Continents: Volume XI","author":"Bray F","year":"2021"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2015.10.011"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14188"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.05.042"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200326010-00004"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006200"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.371"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006083422301"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp467"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/17.4.265"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8546-3-13"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/13697130903060081"},{"key":"e_1_2_10_33_1","unstructured":"United States Renal Data System (USRDS).2020 USRDS Annual Data Report: Epidemiology of kidney disease in the United States. Bethesda United States: National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases2020."},{"issue":"2","key":"e_1_2_10_34_1","first-page":"166","article-title":"Are chronic dialysis patients at increased risk for cancer?","volume":"21","author":"Mandayam S","year":"2008","journal-title":"J Nephrol"},{"key":"e_1_2_10_35_1","article-title":"Increased upper and lower tract urothelial carcinoma in patients with end\u2010stage renal disease: a nationwide cohort study in Taiwan during 1997\u20102008","volume":"2014","author":"Wang SM","year":"2014","journal-title":"Biomed Res Int"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08838.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.1995.tb00465.x"},{"key":"e_1_2_10_38_1","volume-title":"Yearbook of Earnings and Productivity Statistics, Taiwan area, Republic of China, 1996","author":"Directorate General of Budget, Accounting and Statistics (DGBAS)","year":"1997"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1539\/joh.46.440"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12995-016-0128-3"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15102061"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.9b00464"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17093105"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16152746"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331978904000606"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1081\/GNC-200051860"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T14:52:10Z","timestamp":1691765530000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":45,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/cam4.6084"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6084","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]}}}