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Current treatment approaches are insufficient and can only temporarily relieve symptoms. New insights into the physiopathology of radiation\u2010induced xerostomia might help us in this regard. This review discusses the current knowledge of salivary gland stem cells in radiation\u2010induced xerostomia and their value in the prevention and treatment of this complication. Salivary gland stem cell transplantation, bone marrow\u2010derived cell mobilization, molecular regulation of parotid stem cells, stem cell sparing <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>, and adaptive <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> are promising techniques that are discussed in this study.<\/jats:p>","DOI":"10.1002\/cam4.609","type":"journal-article","created":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T09:35:18Z","timestamp":1455615318000},"page":"1147-1153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The role of stem cells in the prevention and treatment of radiation\u2010induced xerostomia in patients with head and neck cancer"],"prefix":"10.1002","volume":"5","author":[{"given":"Daan","family":"Nevens","sequence":"first","affiliation":[{"name":"Radiation Oncology Leuven Cancer Institute University Hospitals Leuven and Department of 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