{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:24Z","timestamp":1786977324984,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>EGFR\u2010mutant (EGFR\u2010M) and ALK\u2010positive (ALK\u2010P)are common in malignant pleural effusion (MPE) with metastatic non\u2010small\u2010cell lung cancer (NSCLC) (MPE\u2010NSCLC). The impact of thoracic tumor radiotherapy on survival in such patients remains unclear. We aimed to investigate whether thoracic tumor radiotherapy could improve overall survival (OS) in such patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>According to whether or not patients accepted thoracic tumor radiotherapy, 148 patients with EGFR\u2010M or ALK\u2010P MPE\u2010NSCLC treated with targeted therapy were classified into two groups: DT group without thoracic tumor radiotherapy and DRT group with thoracic tumor radiotherapy. Propensity score matching (PSM) was performed to balance clinical baseline characteristics. Overall survival was analyzed by Kaplan\u2013Meier, compared by log\u2010rank test, and evaluated using Cox proportional hazards model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median survival time (MST) was 25\u2009months versus 17\u2009months in the DRT group and DT group. The OS rates at 1, 2, 3, 5\u2009years in the DRT group and DT group were 75.0%, 52.8%, 26.8%, 11.1% and 64.5%, 28.4%, 9.2%, 1.8%, respectively (\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200912.028,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Compared with DT group, the DRT group still had better survival after PSM (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). Before and after PSM, factors associated with better OS through multivariable analysis were that thoracic tumor radiotherapy, radiotherapy, N\n                      <jats:sub>0\u20102<\/jats:sub>\n                      , and ALK\u2010TKIs. Grades 4\u20135 radiation toxicities were not observed in patients; 8 (11.6%) and 7 (10.1%) out of the DRT group suffered from Grade 3 radiation esophagitis and radiation pneumonitis, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results for EGFR\u2010M or ALK\u2010P MPE\u2010NSCLC showed that thoracic tumor radiotherapy may be crucial factor in improving OS with acceptable toxicities. Potential biases should not be neglected: Further randomized controlled trials are necessary to confirm this result.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.6130","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T07:54:51Z","timestamp":1686210891000},"page":"14949-14959","source":"Crossref","is-referenced-by-count":3,"title":["Impact of thoracic tumor radiotherapy on survival in non\u2010small\u2010cell lung cancer with malignant pleural effusion treated with targeted therapy: Propensity score matching study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6895-3495","authenticated-orcid":false,"given":"Qingsong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Thoracic Oncology Affiliated Hospital of Guizhou Medical University  Guiyang China"},{"name":"Department of Thoracic Oncology Affiliated Cancer Hospital of Guizhou Medical University  Guiyang China"},{"name":"Teaching and Research Department of Oncology Clinical Medical College of Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology Affiliated Hospital of Guizhou Medical University  Guiyang China"},{"name":"Department of Thoracic Oncology Affiliated Cancer Hospital of Guizhou Medical University  Guiyang China"},{"name":"Teaching and Research Department of Oncology Clinical Medical College of Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengfa","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology Affiliated Hospital of Guizhou Medical University  Guiyang China"},{"name":"Department of Thoracic Oncology Affiliated Cancer Hospital of Guizhou Medical University  Guiyang China"},{"name":"Teaching and Research Department of Oncology Clinical Medical College of Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology Affiliated Hospital of Guizhou Medical University  Guiyang China"},{"name":"Department of Thoracic Oncology Affiliated Cancer Hospital of Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5157-4571","authenticated-orcid":false,"given":"Yichao","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology Affiliated Hospital of Guizhou Medical University  Guiyang China"},{"name":"Department of Thoracic Oncology Affiliated Cancer Hospital of Guizhou Medical University  Guiyang China"},{"name":"Teaching and Research Department of Oncology Clinical Medical College of Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinxiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology Affiliated Hospital of Guizhou Medical University  Guiyang China"},{"name":"Department of Thoracic Oncology Affiliated Cancer Hospital of Guizhou Medical University  Guiyang China"},{"name":"Teaching and Research Department of Oncology Clinical Medical College of Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijie","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology Affiliated Hospital of Guizhou Medical University  Guiyang China"},{"name":"Department of Thoracic Oncology Affiliated Cancer Hospital of Guizhou Medical University  Guiyang China"},{"name":"Teaching and Research Department of Oncology Clinical Medical College of Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology Affiliated Hospital of Guizhou Medical University  Guiyang China"},{"name":"Department of Thoracic Oncology Affiliated Cancer Hospital of Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology Affiliated Hospital of Guizhou Medical University  Guiyang China"},{"name":"Department of Thoracic Oncology Affiliated Cancer Hospital of Guizhou Medical University  Guiyang China"},{"name":"Teaching and Research Department of Oncology Clinical Medical College of Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2013.11.007"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205285"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-2199"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.50.5453"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.21037\/jovs.2018.05.02"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S95663"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011954"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5413"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30498-3"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716948"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1758834010370698"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70232-7"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30565-2"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1612674"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx703"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21700"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000648"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2017.03.010"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3182745948"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31827e1f83"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30532-0"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.11.017"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2019.02.006"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4894"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2012.04179.x"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00069812"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12496"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025748"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12658"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.12629"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.04.045"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-6-166"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.02.054"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2013.07.026"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.08.012"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3718"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019-0285"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2019.07.007"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00167407"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2017.378"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-018-0186-7"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.05.019"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2017.04.035"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-3547"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.12.009"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4192"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12305"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.07.011"},{"key":"e_1_2_12_51_1","volume-title":"A Comparison of the Currently Used Nodal Stage Classification with the Number of Metastatic Lymph Nodes and the Number of Metastatic Lymph Node Stations for Non\u2010Small Cell Lung Cancer","author":"Citak N","year":"2019"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000215"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2010.12.007"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.12.035"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000126"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T10:48:56Z","timestamp":1691750936000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,8]]},"references-count":54,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/cam4.6130"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6130","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,8]]}}}