{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:25Z","timestamp":1786977325006,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T00:00:00Z","timestamp":1686960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,7]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Breast cancer\u2010related lymphedema (BCRL) is one of the common postoperative complications that severely affects the functions of the arm and quality of life. Since lymphedema is difficult to treat and prone to recurrence, early prevention of lymphedema is crucial.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patient diagnosed with breast cancer (\n N<\/jats:italic>\n \u2009=\u2009108) were randomized to the intervention (\n n<\/jats:italic>\n \u2009=\u200952) or control group (\n n<\/jats:italic>\n \u2009=\u200956). In the intervention group, patients were provided the lymphedema prevention program based on the theory of knowledge\u2013attitude\u2013practice during the perioperative period and the first three chemotherapy sessions (mainly includes health education, seminars, knowledge manuals, sports guidance, peer education, and WeChat group).The limb volume, handgrip strength, arm function, and quality of life were measured in all patients at the baseline, 9\u2009weeks (T1), and 18\u2009weeks (T2) after surgery.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The incidence of lymphedema in the Intervention group was numerically lower than in the control group after implementing the lymphedema prevention program, but the difference was not statistically significant (T1: 1.9% vs. 3.8%,\n p<\/jats:italic>\n \u2009=\u20091.000; T2: 3.6% vs. 7.1%,\n p<\/jats:italic>\n \u2009=\u20090.744). However, compared with the control group, the intervention group showed there was less deterioration in handgrip strength (T1 [\n t<\/jats:italic>\n \u2009=\u2009\u22122.512,\n p<\/jats:italic>\n \u2009<\u20090.05] and T2 [\n t<\/jats:italic>\n \u2009=\u2009\u22122.538,\n p<\/jats:italic>\n \u2009<\u20090.05]), improved postoperative upper limb dysfunction (T1 [\n t<\/jats:italic>\n \u2009=\u20093.087,\n p<\/jats:italic>\n \u2009<\u20090.05] and T2 [\n t<\/jats:italic>\n \u2009=\u20095.399,\n p<\/jats:italic>\n \u2009<\u20090.05]) and less deterioration in quality of life (T1 [\n p<\/jats:italic>\n \u2009<\u20090.05] and T2 [\n p<\/jats:italic>\n \u2009<\u20090.05]).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Although the investigated lymphedema prevention program improved arm function and quality of life, it did not reduce the incidence of lymphedema in postoperative breast cancer patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cam4.6171","type":"journal-article","created":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T04:04:11Z","timestamp":1686974651000},"page":"15468-15481","source":"Crossref","is-referenced-by-count":17,"title":["Effects of a lymphedema prevention program based on the theory of knowledge\u2013attitude\u2013practice on postoperative breast cancer patients: A randomized clinical trial"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1972-9542","authenticated-orcid":false,"given":"Bohui","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Breast Surgery, The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Nursing Xi'an Jiaotong University Health Science Center Xi'an Shaanxi 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