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Pairwise comparisons and ranking of different first\u2010line treatment options were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine studies were included in the NMA, involving a total of 2897 MCL patients. The BR\u2010Ibrutinib+R regimen showed the best progression\u2010free survival (PFS), with a surface under the cumulative ranking curve (SUCRA) of 0.89 and probability of being the best treatment (PbBT) of 69%. The VR\u2010CAP regimen was the most potential intervention to improve overall survival (OS), with a SUCRA of 0.89 and PbBT of 63%. Compared with the R\u2010CHOP regimen, the BR regimen achieved a better PFS (hazard ratio [HR] 0.45 [95% credible interval 0.2\u20130.96]). The BR\u2010Ibrutinib+R regimen (HR 0.14 [0.02\u20130.99]), BR+R regimen (HR 0.19 [0.034\u20130.99]), and BR regimen (HR 0.3 [0.08\u20131.03]) were superior to CHOP regimen with better PFS. The R\u2010FC regimen (HR 2.27 [1.01\u20135.21]) or FC regimen (HR 3.17 [1.15\u20138.71]) was inferior to the VR\u2010CAP regimen with a worse OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study presents the most promising first\u2010line treatment strategy for transplant\u2010ineligible MCL patients in terms of PFS and OS, which provides innovative treatment strategy for MCL treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6183","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T13:16:22Z","timestamp":1685711782000},"page":"15107-15116","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of front\u2010line immunochemotherapy for transplant\u2010ineligible mantle cell lymphoma: A network meta\u2010analysis of randomized controlled 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