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Previous studies identified single nucleotide variants (<jats:styled-content style=\"fixed-case\">SNV<\/jats:styled-content>) associated with <jats:styled-content style=\"fixed-case\">PIPN<\/jats:styled-content>. However, only a subset of findings has been confirmed to date in more than one study, suggesting a need for further re\u2010testing and validation in additional clinical cohorts. Candidate <jats:styled-content style=\"fixed-case\">PIPN<\/jats:styled-content>\u2010associated <jats:styled-content style=\"fixed-case\">SNVs<\/jats:styled-content> were identified from the literature. <jats:styled-content style=\"fixed-case\">SNVs<\/jats:styled-content> were retested in 119 patients selected by extreme phenotyping from 269 in <jats:styled-content style=\"fixed-case\">NCCTG<\/jats:styled-content> N08C1 (Alliance) as previously reported. <jats:styled-content style=\"fixed-case\">SNV<\/jats:styled-content> genotyping was performed by a combination of short\u2010read sequencing analysis and Taqman <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. These 22 candidate <jats:styled-content style=\"fixed-case\">PIPN SNVs<\/jats:styled-content> were genotyped. Two of these, rs7349683 in the <jats:italic><jats:styled-content style=\"fixed-case\">EPHA<\/jats:styled-content>5<\/jats:italic> and rs3213619 in <jats:italic><jats:styled-content style=\"fixed-case\">ABCB<\/jats:styled-content>1<\/jats:italic> were found to be significantly associated with <jats:styled-content style=\"fixed-case\">PIPN<\/jats:styled-content> with an Odds ratios <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.07 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.12 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), respectively. In addition, three <jats:styled-content style=\"fixed-case\">SNVs<\/jats:styled-content> showed a trend toward a risk\u2010 or protective effect that was consistent with previous reports. The rs10509681 and rs11572080 in the gene <jats:italic><jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2C8*3<\/jats:italic> showed risk effect with an <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.49 and rs1056836 in <jats:italic><jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>1B1<\/jats:italic> showed a protective effect with an <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.66. None of the other results supported the previously reported associations, including some <jats:styled-content style=\"fixed-case\">SNVs<\/jats:styled-content> displaying an opposite direction of effect from previous reports, including rs1058930 in <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2C8, rs17222723 and rs8187710 in <jats:italic><jats:styled-content style=\"fixed-case\">ABCC<\/jats:styled-content>2<\/jats:italic>, rs10771973 in <jats:italic><jats:styled-content style=\"fixed-case\">FGD<\/jats:styled-content>4<\/jats:italic>, rs16916932 in <jats:styled-content style=\"fixed-case\">CACNB<\/jats:styled-content>2 and rs16948748 in <jats:italic><jats:styled-content style=\"fixed-case\">PITPNA<\/jats:styled-content><\/jats:italic>. Alliance N08C1 validated or supported a minority of previously reported <jats:styled-content style=\"fixed-case\">SNV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PIPN<\/jats:styled-content> associations. Associations previously reported by multiple studies appeared to have a higher likelihood to be validated by Alliance N08C1.<\/jats:p>","DOI":"10.1002\/cam4.625","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T12:07:03Z","timestamp":1452773223000},"page":"631-639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Testing of candidate single nucleotide variants associated with paclitaxel neuropathy in the trial <scp>NCCTG<\/scp> N08C1 (Alliance)"],"prefix":"10.1002","volume":"5","author":[{"given":"Ganesh K.","family":"Boora","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Kanwar","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Mayo Clinic  Rochester 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