{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T06:56:20Z","timestamp":1763535380207,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T00:00:00Z","timestamp":1452816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007300","name":"China Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007300","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW104\u2010TDU\u2010B\u2010212\u2010113002"],"award-info":[{"award-number":["MOHW104\u2010TDU\u2010B\u2010212\u2010113002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI\u2010EX101\u201010124SC","NHRI\u2010EX102\u201010124SC","NHRI\u2010EX103\u201010124SC","NHRI\u2010EX104\u201010124SC"],"award-info":[{"award-number":["NHRI\u2010EX101\u201010124SC","NHRI\u2010EX102\u201010124SC","NHRI\u2010EX103\u201010124SC","NHRI\u2010EX104\u201010124SC"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2016,4]]},"abstract":"Abstract<\/jats:title>Despite good clinical results of current drugs, a good reason still exists to search for additional therapies for the management of Chronic Myeloid Leukemia (CML<\/jats:styled-content>). Chinese Herbal Medicine (CHM<\/jats:styled-content>) has thus far been overlooked by researchers and no data exists on the subject. We studied the impact of adjunctive CHM<\/jats:styled-content> on the disease course of CML<\/jats:styled-content>, using mortality as the major outcome measurement. We used the Taiwanese National Health Insurance Research Database to perform a nationwide population\u2010based cohort study. Our study included CML<\/jats:styled-content> patients diagnosed between 2000 and 2010. We matched groups according to age, sex, Charlson Comorbidity Index (CCI<\/jats:styled-content>) score and use of imatinib, and compared the Hazard Ratios (HR<\/jats:styled-content>) of CHM<\/jats:styled-content> group and non\u2010CHM<\/jats:styled-content> users, as well as characterized trends of prescriptions used for treating CML<\/jats:styled-content>. 1371 patients were diagnosed with CML<\/jats:styled-content> in the years examined, of which 466 were included in to this study. We found that the HR<\/jats:styled-content> of CHM<\/jats:styled-content> group was significantly lower compared to non\u2010CHM<\/jats:styled-content> groups (0.32, 95% CI<\/jats:styled-content> 0.22\u20130.48, P<\/jats:italic>\u00a0<\u00a00.0001). We also established that this association between reduced HR<\/jats:styled-content> was dose\u2010dependent, and the longer CHM<\/jats:styled-content> users received prescriptions, the lower the HR<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.01). We also analyzed the most commonly used herbal products as well as the HR<\/jats:styled-content> associated to their use, thus providing future research candidates. Our results supply a strong reason to assume that when administered by properly trained physicians, CHM<\/jats:styled-content> may have a substantial positive impact on the management of CML<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/cam4.627","type":"journal-article","created":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T18:06:14Z","timestamp":1452967574000},"page":"640-648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Adjunctive Chinese Herbal Medicine therapy improves survival of patients with chronic myeloid leukemia: a nationwide population\u2010based cohort study"],"prefix":"10.1002","volume":"5","author":[{"given":"Tom","family":"Fleischer","sequence":"first","affiliation":[{"name":"Graduate Institute of Chinese Medicine College of Chinese Medicine China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tung\u2010Ti","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Chinese Medicine China Medical University Hospital Taichung Taiwan"},{"name":"School of Chinese Medicine China Medical University Taichung Taiwan"},{"name":"School of Post\u2010baccalaureate Chinese Medicine China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen\u2010Huai","family":"Chiang","sequence":"additional","affiliation":[{"name":"Management Office for Health Data China Medical University Hospital Taichung Taiwan"},{"name":"Graduate Institute of Integrated Medicine College of Chinese Medicine China Medical University Taichung Taiwan"},{"name":"Research Center for Chinese Medicine and Acupuncture China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Mao","family":"Chang","sequence":"additional","affiliation":[{"name":"Center for Traditional Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine Graduate Institute of Traditional Chinese Medicine College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Yun","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Internal Medicine China Medical University Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0131-1658","authenticated-orcid":false,"given":"Hung\u2010Rong","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Chinese Medicine China Medical University Hospital Taichung Taiwan"},{"name":"School of Chinese Medicine China Medical University Taichung Taiwan"},{"name":"Research Center for Chinese Medicine and Acupuncture China Medical University Taichung Taiwan"},{"name":"Research Center for Traditional Chinese Medicine Department of Medical Research China Medical University Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062867"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306494"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.225"},{"key":"e_1_2_7_5_1","first-page":"1126","article-title":"International Randomized Study of Interferon Vs STI571 (IRIS) 8\u2010Year Follow up: sustained Survival and Low Risk for Progression or Events in Patients with Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase (CML\u2010CP) Treated with Imatinib","volume":"114","author":"Deininger M.","year":"2009","journal-title":"ASH Ann.Meet. 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