{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T05:34:58Z","timestamp":1772602498850,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Metastatic ocular and orbital melanomas are extremely rare. The clinical characteristics and standard treatments for these patients are not fully established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We retrospectively analyzed patients with metastatic ocular and orbital melanoma from Fudan University Shanghai Cancer Center and Eye &amp; ENT Hospital of Fudan University between January 2012 and May 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 51 patients with metastatic ocular and orbital melanoma were included. The most common primary sites were uvea (73%), followed by conjunctiva (22%), lacrimal sac (4%), and orbit (2%). Patients with uveal melanoma (UM) had a significantly younger age (48 vs. 68\u2009years, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), higher incidence of liver metastases (89% vs. 9%, <jats:italic>p<\/jats:italic>&lt;0.001), a lower incidence of lymph nodes metastases (16% vs. 46%, <jats:italic>p<\/jats:italic>\u2009=\u20090.043) and a lower incidence of <jats:italic>BRAF<\/jats:italic> mutation (0% vs. 55%, <jats:italic>p<\/jats:italic>&lt;0.001) compared with patients with conjunctival melanoma (CM). The overall response rate of the first\u2010line treatment was 18%. Three of the four patients with <jats:italic>BRAF<\/jats:italic>\u2010mutated CM responded to dabrafenib and trametinib treatment. The median progression\u2010free survival (PFS) and overall survival (OS) of first\u2010line treatment were 5.1 and 11.9\u2009months, respectively. Among patients with liver metastases, liver\u2010directed treatment was correlated with better patient PFS (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and OS (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) after adjusting for number of metastatic sites and primary sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CM and UM have different characteristics. Patient with CM had a high incidence of <jats:italic>BRAF<\/jats:italic> mutation, and the treatment of BRAF and MEK inhibitors conferred clinical benefit. Liver directed therapies had a potential benefit in disease control in patients with liver metastases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6273","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T09:05:13Z","timestamp":1688634313000},"page":"16163-16172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical features and prognosis of patients with metastatic ocular and orbital melanoma: A bi\u2010institutional study"],"prefix":"10.1002","volume":"12","author":[{"given":"Xin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Head &amp; Neck tumors and Neuroendocrine tumors Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College, Fudan University  Shanghai 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