{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:14:03Z","timestamp":1784661243206,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The aim of this retrospective study was to investigate the clinicopathological characteristics of AYA sarcomas and their clinical outcomes at a high\u2010volume single center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Demographic, clinicopathological data on the diagnosis, treatment and follow\u2010up of all sarcoma patients aged 16\u201339\u2009years (ys) observed at our Institute between January 2010 and December 2021 were retrospectively collected, including diagnostic (TTD) and treatment delay(TTT), clinical outcomes (OS and PFS), and late\u2010treatment effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 228 AYA patients, median age 30\u2009years, 29%\u2009\u2264\u200925\u2009years, 57% males, 88% soft tissue sarcomas (STS), and 12% bone sarcomas (BS). Among STSs, 13% were small round cell tumors (SRCT), 52% intermediate\u2013high\u2010grade, 24% low\u2010grade STSs. Among BS, 32% were high\u2010grade. Median TTD and TTT were 120 (0\u20138255) and 7\u2009days (0\u201383), respectively. Surgery was performed in 83%, radiotherapy in 29%, and systemic therapy in 27%. Median follow\u2010up was 72.9\u2009months(1.6\u2013145), 5\u2010year and 10\u2010year OS were 78.5% and 62%, respectively. Kaplan\u2013Meyer analysis showed a significantly better 5\u2010year OS and PFS for patients with &gt;92\u2009days of TTD (OS 85.7% vs. 66.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001, PFS 50.2% vs. 24.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.009). According to age (\u226425\u2009years vs.\u2009&gt;\u200925\u2009years), 5\u2010year OS was 69.8% versus 82.2%, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.047).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our analysis confirmed previous data on sarcoma AYA patients followed in a referral center. Unexpectedly, diagnostic delay was not associated with poor OS and PFS. Patients &lt;25\u2009years showed a poorer prognosis due to the higher incidence of SRCT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6289","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T10:49:09Z","timestamp":1687862949000},"page":"16254-16263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multidisciplinary management of adolescents and young adults (<scp>AYA<\/scp>) sarcoma: A successful effort of an adult high\u2010volume cancer center"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8933-9929","authenticated-orcid":false,"given":"Alexia Francesca","family":"Bertuzzi","sequence":"first","affiliation":[{"name":"Department of Oncology &amp; Hematology IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Susanna","family":"Grimaudo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7458-3366","authenticated-orcid":false,"given":"Alice","family":"Laffi","sequence":"additional","affiliation":[{"name":"Department of Oncology &amp; Hematology IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Giordano","sequence":"additional","affiliation":[{"name":"Biostatistic Unit IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7259-6980","authenticated-orcid":false,"given":"Nicol\u00f2","family":"Gennaro","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University  Chicago USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Cariboni","sequence":"additional","affiliation":[{"name":"Department of Surgery IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9036-7444","authenticated-orcid":false,"given":"Licia Vanessa","family":"Siracusano","sequence":"additional","affiliation":[{"name":"Department of Oncology &amp; Hematology IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Quagliuolo","sequence":"additional","affiliation":[{"name":"Department of Surgery IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piergiuseppe","family":"Colombo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Italy"},{"name":"Department of Pathology IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-4272","authenticated-orcid":false,"given":"D\u2019Orazio","family":"Federico","sequence":"additional","affiliation":[{"name":"Department of Radiology IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0186-1318","authenticated-orcid":false,"given":"Salvatore Lorenzo","family":"Renne","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Italy"},{"name":"Department of Pathology IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Specchia","sequence":"additional","affiliation":[{"name":"Department of Gynecology IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8227-3373","authenticated-orcid":false,"given":"Ferdinando","family":"Cananzi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Italy"},{"name":"Department of Surgery IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2583-5226","authenticated-orcid":false,"given":"Andrea","family":"Marrari","sequence":"additional","affiliation":[{"name":"Department of Oncology Istituto Ortopedico Rizzoli  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierina","family":"Navarria","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Radiosurgery IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Primo Andrea","family":"Daolio","sequence":"additional","affiliation":[{"name":"Department of Orthopedics ASST\u2010Gaetano Pini\u2010CTO  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bastoni","sequence":"additional","affiliation":[{"name":"Department of Orthopedics ASST\u2010Gaetano Pini\u2010CTO  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1709-9492","authenticated-orcid":false,"given":"Armando","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Oncology &amp; Hematology IRCCS Humanitas Research Hospital  Rozzano Italy"},{"name":"Department of Biomedical Sciences Humanitas University  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30589"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32367"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2011.06.005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30099-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11259"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5409\/wjcp.v4.i4.94"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8639272"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2019-000592"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.18.00684"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.19.00145"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1188\/15.CJON.19-06AP"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2010.81"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2005.03.007"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.8312"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.15_suppl.e18034"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)00162-5"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800831105"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj517"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh058"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018-0751"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-008-0162-4"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-12-82"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2019.02.012"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.08.007"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2017.0095"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2012.705891"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10269-007-0599-z"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0025"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.07.006"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt031"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30086"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33931"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00722"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13194847"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22102"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2349"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2020.03.218"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T09:33:06Z","timestamp":1715765586000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,27]]},"references-count":37,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/cam4.6289"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6289","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,27]]},"assertion":[{"value":"2023-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}