{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:26:23Z","timestamp":1764937583914,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:00:00Z","timestamp":1688515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In myelodysplastic neoplasms (MDS), the 20q deletion [del(20q)] is a recurrent chromosomal abnormality that it has a high co\u2010occurrence with <jats:italic>U2AF1<\/jats:italic> mutations. Nevertheless, the prognostic impact of <jats:italic>U2AF1<\/jats:italic> in these MDS patients is uncertain and the possible clinical and\/or prognostic differences between the mutation type and the mutational burden are also unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our study analyzes different molecular variables in 100 MDS patients with isolated del(20q).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results &amp; Conclusions<\/jats:title><jats:p>We describe the high incidence and negative prognostic impact of <jats:italic>U2AF1<\/jats:italic> mutations and other alterations such as in <jats:italic>ASXL1<\/jats:italic> gene to identify prognostic markers that would benefit patients to receive earlier treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6300","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T09:39:33Z","timestamp":1688549973000},"page":"16788-16792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Incidence and prognostic impact of <scp><i>U2AF1<\/i><\/scp> mutations and other gene alterations in myelodysplastic neoplasms with isolated 20q deletion"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-4687","authenticated-orcid":false,"given":"Mart\u00edn I.","family":"Castillo","sequence":"first","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Cl\u00ednico Universitario de Valencia, Instituto de Investigaci\u00f3n Sanitaria INCLIVA  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Villam\u00f3n E.","family":"Ribate","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Cl\u00ednico Universitario de Valencia, Instituto de Investigaci\u00f3n Sanitaria INCLIVA  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calabuig M.","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Cl\u00ednico Universitario de Valencia, Instituto de Investigaci\u00f3n Sanitaria INCLIVA  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanz G.","family":"Santillana","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Universitario y Polit\u00e9cnico La Fe, Instituto de Investigaci\u00f3n Sanitaria La Fe, CIBERONC \u2013 ISCIII  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Such E.","family":"Taboada","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Universitario y Polit\u00e9cnico La Fe, Instituto de Investigaci\u00f3n Sanitaria La Fe, CIBERONC \u2013 ISCIII  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mora E.","family":"Caster\u00e1","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Universitario y Polit\u00e9cnico La Fe, Instituto de Investigaci\u00f3n Sanitaria La Fe, CIBERONC \u2013 ISCIII  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calasanz M. J.","family":"Abinzano","sequence":"additional","affiliation":[{"name":"CIMA LAB Diagnostics Universidad de Navarra, CIBERONC \u2013 ISCIII  Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irigoyen A.","family":"Barranco","sequence":"additional","affiliation":[{"name":"CIMA LAB Diagnostics Universidad de Navarra, CIBERONC \u2013 ISCIII  Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Collado R.","family":"Nieto","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Consorcio Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vara M.","family":"Pampliega","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda y Hemoterapia del Hospital Universitario de Cruces  Barakaldo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Blanco","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital de la Santa Creu i Sant Pau  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvarez S.","family":"de Andr\u00e9s","sequence":"additional","affiliation":[{"name":"NIMGenetics, Gen\u00f3mica y Medicina  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9rez J.","family":"de Oteyza","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Universitario HM Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernal T.","family":"del Castillo","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Universidad de Asturias, IISPA, IUOPA  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Granada I.","family":"Font","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital Germans Trias i Pujol, Institut Catal\u00e0 d'Oncologia, Institut de Recerca contra la Leuc\u00e8mia Josep Carreras Universidad Aut\u00f3noma de Barcelona, CIBERONC \u2013 ISCIII  Bellaterra Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerez A.","family":"Cayuela","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Universitario Morales Meseguer  Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"D\u00edez\u2010Campelo","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Universitario de Salamanca, CIBERONC \u2013 ISCIII  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abell\u00e1n R.","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Patolog\u00eda Molecular Hospital Cl\u00ednico Universitario de Valencia, Instituto de Investigaci\u00f3n Sanitaria INCLIVA  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