{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:38:15Z","timestamp":1747147095016,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We have reported that seroconversion rates after the second dose of mRNA\u2010based COVID\u201019 vaccines for myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) were 100% and 95% respectively, with no significant difference from healthy controls (HCs).However, there are very limited data for the response to a third vaccine dose in those patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>In this complementary study, we investigated the booster effect of a third mRNA\u2010based COVID\u201019 vaccine dose in patients with myeloid malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials &amp; Methods<\/jats:title><jats:p>A total 58 patients including 20 patients with MDS and 38 patients with AML were enrolled. Anti\u2010SARS\u2010CoV\u20102S immunoassays were performed at 3, 6, and 9 months after the second vaccine dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010five percent of the MDS patients and 37% of the AML patients were receiving active treatment at the time of the third vaccination. Both the initial and third vaccine response in AML patients were comparable to those in HCs. In MDS patients, although the initial vaccine immunogenicity was inferior to that in HCs and AML patients, the third vaccine improved the response to a level not inferior to those in HCs and AML patients. Of note, the third vaccine resulted in a significant increase of antibodies in actively treated MDS patients who had shown a response inferior to that in untreated patients after two doses of vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In patients with myeloid malignancies, the third vaccine dose showed a booster effect, and disease\u2010 and therapy\u2010related factors associated with the booster response have been identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The third dose of an mRNA\u2010based COVID\u201019 vaccine showed a booster effect in patients with myeloid malignancies. Such a good booster response has not been reported in other haematological malignancies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6314","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T10:24:01Z","timestamp":1688639041000},"page":"16881-16888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Booster effect of a third <scp>mRNA<\/scp>\u2010based <scp>COVID<\/scp>\u201019 vaccine dose in patients with myeloid malignancies"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2064-2145","authenticated-orcid":false,"given":"Akio","family":"Mori","sequence":"first","affiliation":[{"name":"Blood Disorders Center Aiiku Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9267-2864","authenticated-orcid":false,"given":"Masahiro","family":"Onozawa","sequence":"additional","affiliation":[{"name":"Department of Hematology Hokkaido University Faculty of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7340-5277","authenticated-orcid":false,"given":"Mirei","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Blood Disorders Center Aiiku Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3198-0796","authenticated-orcid":false,"given":"Shihori","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Blood Disorders Center Aiiku Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5382-5167","authenticated-orcid":false,"given":"Hajime","family":"Senjo","sequence":"additional","affiliation":[{"name":"Blood Disorders Center Aiiku Hospital  Sapporo Japan"},{"name":"Department of Hematology Hokkaido University Faculty of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ishio","sequence":"additional","affiliation":[{"name":"Blood Disorders Center Aiiku Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Blood Disorders Center Aiiku Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0035-8657","authenticated-orcid":false,"given":"Minoru","family":"Kanaya","sequence":"additional","affiliation":[{"name":"Blood Disorders Center Aiiku Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0762-6255","authenticated-orcid":false,"given":"Koh","family":"Izumiyama","sequence":"additional","affiliation":[{"name":"Blood Disorders Center Aiiku Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2683-9475","authenticated-orcid":false,"given":"Makoto","family":"Saito","sequence":"additional","affiliation":[{"name":"Blood Disorders Center Aiiku Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruna","family":"Muraki","sequence":"additional","affiliation":[{"name":"Division of Laboratory Aiiku Hospital  Sapporo Japan"},{"name":"Sapporo Clinical Laboratory Inc.  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