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Fifty\u2010Five patients received intensive chemotherapy (IC), 33 non\u2010IC, and 24 best supportive care. At t\u2010AML diagnosis, 42% and 44% of patients presented an unfavorable karyotype and unfavorable 2010 ELN risk profile, respectively. Among treated patients (<jats:italic>n<\/jats:italic>\u2009=\u200988), 43 (49%) achieved complete remission: four out of 33 (12%) and 39 out of 55 (71%) in non\u2010IC and IC groups, respectively. With a median follow\u2010up of 5.5\u2009months, the median overall survival (OS) and disease\u2010free survival (DFS) for the whole population were 9\u2009months and 6.3\u2009months, respectively, and for the 88 treated patients 13.5\u2009months and 8.2\u2009months, respectively. Univariate analysis on OS and DFS showed a significant impact of high white blood cells (WBC) and blast counts at diagnosis, unfavorable karyotype and ELN classification. Multivariate analysis showed a negative impact of WBC count at diagnosis and a positive impact of chemotherapy on OS and DFS in the whole population. It also showed a negative impact of previous auto\u2010HCT and high WBC count on OS and DFS and of IC on OS in treated patients which disappeared when we considered only confounding variables (age, previous cancers, marrow blasts, and 2010 ELN classification). In a pair\u2010matched analysis comparing IC treated t\u2010AML with de novo AML, there was no difference of OS and DFS between the two populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We showed, in this study that t\u2010AML patients with unfavorable features represented almost half of the population. Best outcomes obtained in patients receiving IC must be balanced by known confounding variables and should be improved by using new innovative agents and therapeutic strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6322","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T11:46:40Z","timestamp":1691408800000},"page":"16929-16944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical outcome of therapy\u2010related acute myeloid leukemia patients. 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